Research Overview

Science Highlights

The science highlights feature high impact research based on data totally or partially collected at the SSRL macromolecular crystallography beamlines. Many of these scientific highlights have been included in reports to funding agencies and have been reported by other media. Users are strongly encouraged to contact SSRL or use the Publication Reporting Form when exciting results are about to be published.

A Spider Toxin Catches a Sodium Channel Involved in Pain Perception in Action, November 2019

Structure and Functional Binding Epitopes of V-domain Ig Suppressor of T-Cell Activation (VISTA), September 2019

Structure of the Full-length Clostridium difficile Toxin B, August 2019

Winning the Fight against Influenza, May 2019

Doubling the DNA Alphabet: Implications for Life in the Universe and DNA Storage, March 2019

Mechanism of Thiopurine Resistance in Acute Lymphoblastic Leukemia, February 2019

Structural Basis of Neurosteroid Anesthetic Action on GABAA Receptors, February 2019

A Structural Switch that Couples TCR Ligand Binding to Signaling, December 2018

Revealing the Functional Principles of a Multi-protein Assembly that Uses MicroRNAs, October 2018

Structural Study of Potent Peptidic Fusion Inhibitors of Influenza Virus Hemagglutinin, March 2018

Muscle Disorders at High Resolution: Native American Myopathy and Beyond, March 2018

Demanding Catalysis via Energy-conserving Electron Bifurcation, October 2017

Structure of the Human Cysteine Desulfurase Complex, September 2017

Structures of the CRISPR Genome Integration Complex, August 2017

Structures of the CRISPR Genome Integration Complex, August 2017

Elucidating the Role of POT1 C-terminal Mutations in Cancer, April 2017

Inhibition of the Gas6/Axl Pathway Augments the Efficacy of Chemotherapies, January 2017

Structure of the Cell’s DNA Gatekeeper, August 2016

A New Type of Pilus from the Human Microbiome, July 2016

Structure, Inhibition and Regulation of Two-pore Channel TPC1 from Arabidopsis thaliana, March 2016

Discovery of Next Generation RAF Inhibitors that Dissociate Paradoxical Activation from Inhibition of the MAPK Pathway, February 2016

Revealing a New Conformational State in a Chloride/Proton Exchanger, January 2016

Translocator Protein Structure and Function, November 2015

Goniometer-based Femtosecond Macromolecular Crystallography, October 2015

Crystal Structures of the Synaptotagmin-SNARE Complex that is Essential for Synchronous Synaptic Neurotransmitter Release, October 2015

Discovery of the Fundamental Mechanism of Action of Resveratrol, May 2015

A Designed Supramolecular Protein Assembly with in-Vivo Enzymatic Activy, April 2015

Reversible CO-binding to the Active Site of Nitrogenase, March 2015

Crystal Structure of Cascade, January 2015

CRISPR RNA-guided Surveillance in Escherichia Coli, January 2015

Antibody Recognition of the Influenza Hemagglutinin by Receptor Mimicry, November 2014

A New Link between Human and Bacterial Signaling Machineries, September 2014

Deconstructing the Peptide-MHC Specificity of T Cell Recognition, May 2014

Fatty Acid Biosynthesis Caught in the Act, March 2014

Structural Rearrangement in Ebola Virus Protein VP40 Creates Multiple Functions, March 2014

Structure of Chinese Herbal-based Medicine Captured by ATP on a Human tRNA Synthetase, October 2013

Structure of the DUF2233 Domain in Bacteria and the Stuttering-associated UCE Glycoprotein, July 2013

Crystal Structure and Functional Analysis Identify Evolutionary Secret of SerRS in Vascular Development, July 2013

Structure of Human Argonaute2: A Programmable Ribonuclease, July 2013

The Long-Sought Structure of a-Catenin Defines Its Functions for Cell-Cell Interactions, June 2013

The Structure and Dynamics of Eukaryotic Glutaminyl-tRNA Synthetase, May 2013

Allosteric Activation and Modulation of Pentameric Ligand-gated Ion Channels, April 2013

Structural Basis for Iron Piracy by Pathogenic Neisseria, January 2013

The Lassa Virus Nucleoprotein Appears to Exhibit Conformational Control of Genome Binding, January 2013

Botulinum Neurotoxin is Bio-shielded by NTNHA in a Handshake Complex, October 2012

Folate Binding Site of Flavin-dependant Thymidylate Synthase and the Mechanistic Implications, September 2012

Structural Basis of Wnt Recognition by Frizzled, September 2012

Computational Design of Anti-flu Proteins, August 2012

SSRL Data Directs Prostate Cancer Drug Design, June 2012

How a Single Receptor Discriminates between a Variety of Different Ligands, April 2012

Structure of an N-terminal T# Peptide Inserted into a Hydrophobic Pocket of the Mammalian C. elegans Homolog, UNC119, April 2012

Structure of an Enzyme Catalyzing an Unfavorable Ring Closure Revealed, March 2012

Structural Basis of Photoactivation of a Bacterial DNA-binding Protein, February 2012

SSRL Data Aids in the Development of a New Robust Method for X-Ray Crystallographic Structure Determination, February 2012

How a Complex Molecular Machine Is Built for Gene Transcription: Architecture of the Mediator Head Module, November 2011

Resolution of a 5′ flap in DNA replication and repair; structures of human Flap endonuclease (FEN1) with DNA substrate and product, October 2011

Proteins Better Analyzed at Room Temperature, Report Finds, September 2011

Controlling Protein Aggregation: Lessons from Fungi, August 2011

Staying One Step Ahead of Antibiotic Resistance, June 2011

Structure of Precursor-Bound NifEN: A Nitrogenase FeMo Cofactor Maturase/Insertase, June 2011

Transcription Starts Here: Structural Models of a “Minimal” Preinitiation Complex, June 2011

Crystal Structures of two Viral IRES RNA domains bound to the 70S ribosome, June 2011

Structure Determination of an Oxidized Enzyme Intermediate, May 2011

Neisseria menindigitis PorB: From Structure to Function to Disease..., April 2011

Crystal structure of human symplekin-Ssu72-CTD phosphopeptide complex, February 2011

Metal templated protein interface design, January 2011

Easy to Get In, Hard to Get Out: X-ray Structure and Mechanism of RNA Polymerase II Stalled at an Antineoplastic Monofunctional Platinum-DNA Adduct, January 2011

Spotting Disease Hot Spots in Ryanodine Receptors, November 2010

Structure of a Cation-bound Multidrug and Toxic Compound Extrusion Transporter, October 2010

Structures of Two Semaphorin-Plexin Complexes Reveal a Basis for Repulsive Guidance Cue Recognition and Viral Mimicry, September 2010

Crystallographic Studies of CO to CO2 Interconversion in a Ni-Fe-S Cluster-containing Metalloenzyme, July 2010

Fragment Screen against HIV Protease: Discovery of Two Allosteric Binding Sites, June 2010

Structural Basis of Pre-existing Immunity to the 2009 H1N1 Pandemic Influenza Virus, May 2010

Assembly and Evolution of Complex Fe-S Clusters as Revealed by X-ray Crystallography, April 2010

Deadly Carcinogen Unraveled: The Molecular Origami of Fungal Polyketides, March 2010

Crystal Structure of the Hexameric Assembly Unit of the HIV Capsid, January 2010

Molecular Mimicry of SUMO by Rad60 Helps Protect the Genome from Toxic Stress, January 2010

An Ancient Structural Bridge Joins Editing to Aminoacylation to Prevent Mistranslation, December 2009

Allosteric Modulation of DNA by Small Molecules, November 2009

Model for Eukaryotic Tail-anchored Protein Binding Based on the Structure of Get3, November 2009

Structure of an Unusually Small RNA Switch Provides Insight into the Minimal Requirements for Microbial Gene Regulation, August 2009

Marine Diatoms Survive Iron Droughts in the Ocean by Storing Iron in Ferritin, June 2009

Structural Studies of Nitric Oxide Synthase Inhibitor Complexes: An Anchored Plasticity Approach for Selective Enzyme Inhibition, April 2009

Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-specific Drug Binding, April 2009

An Unusual Mechanism for the Antimicrobial Target Flavine-dependant Thymidylate Synthase (FTDS), April 2009

Structural and Functional Basis for Broad-spectrum Neutralization of Avian and Human Influenza A Viruses, March 2009

Structure of the Ebola Virus Glycoprotein Bound to an Antibody from a Human Survivor, November 2008

Structure and Activities Shed Light into Cancer and Aging Phenotypes of Helicase XPD Mutations, October 2008

Structure of the Membrane Proximal Oxidoreductase Domain of Human Steap3, the Dominant Ferrireductase of the Erythroid Transferrinn Cycle, September 2008

Structure of the TGF-β Receptor Complex Reveals Evolutionary Adaptations that have Led to Diversification of Function within the Superfamily, May 2008

Snapshots of the IL-4 Receptor Ternary Complexes: An Opportunity to Visualize the Basis of Cytokine Receptor Pleiotropy in the Immune System , April 2008

Cooperation of Rab and Arl GTPase Family Members in Localization of the Golgin GCC185 , January 2008

Structures of the GRP94-Nucleotide Complexes Reveal Mechanistic Differences between the Hsp90 Chaperones , January 2008

The Structures of Synaptic Cell Adhesion Proteins Neuroligin-1 in Isolation and in Complex with Neurexin-1&beta Reveal Specific Protein-Protein and Protein-Ca2+ Interactions , December 2007

Structure of a Thiol Monolayer-Protected Gold Nanoparticle at 1.1 Å Resolution , December 2007

MitoNEET is a Uniquely Folded Outer Mitochondrial Membrane Protein Stabilized by Diabetes Drugs , October 2007

Structural Insights into the Regulation of the SNARE Assembly by the Cell Polarity Protein Sro7 , July 2007

How a Single T Cell Receptor Recognizes Both Self and Foreign MHC , June 2007

Structure of a Putative Metal-Chelate Type ABC Transporter: An Inward-facing Conformation , May 2007

How Might a Pre-biotic Ribozyme Catalyze RNA Assembly in an RNA world? , April 2007

High Resolution Structure of the Neisseria gonorrhoeae Type IV Pilus: A Membrane-bound Fibrous Assembly. , April 2007

Defining How Botulinum Toxin Binds to the Synaptotagmin Receptor and Creating Improved Therapeutics to Block Toxicity, March 2007

Molecular Interaction between Botulinum Neurotoxin B and Its Protein Receptor Revealed, March 2007

Structure of the MTIP-MyoA Complex, a Key Component of the Malaria Parasite Invasion Motor, January 2007

Structural Studies of the Didomain of a 6-Deoxyerythronolide B Synthase:Largest Structure/Asymmetic Unit Solved by MAD Technique, December 2006

Structural Basis of Transciption: Role of the Trigger Loop in SubstrateSpecificity and Catalysis, December 2006

Structure of GDNF Family Ligand Artemin Complexed with Its GFRα3 Receptor, November 2006

The Elusive Active Fold of a Catalytic RNA: A Crystal Structure of a Full-Length Hammerhead Ribozyme, August 2006

Crystal Structure of Iron-dependent Halogenase, June 2006

Controlling DNA Methylation, June 2006

Crystal Structure Sheds Light on Heriditary Coproporphyria, May 2006

Small-Molecule Inhibition of TNF-alpha, April 2006

High Resolution Snapshots for the Complete Reaction Cycle of a Cocaine Catalytic Antibody, March 2006

Crystal Structure of a Conserved Phosphate Domain of Non-structural Protein-3 (nsp3) from the SARS Coronavirus, March 2006

The Crystal Structure of Human, Nicotine Metabolizing Cytochrome P450 2A6, December 2005

Structure of Human Toll-like Receptor 3 (TLR3) Ligand-Binding Domain, September 2005

Structural Basis for the Promiscuous Biosynthetic Prenylation of Aromatic Natural Products, July 2005

Cytoplasmic Domain Structures of Kir2.1 and Kir3.1 Show Sites for Modulating Gating and Rectification, July 2005

Structure of the ESCRT-II Endosomal Trafficking Complex, Feb 2005

Substrate Recognition Strategy for Botulinum Neurotoxin Serotype A, Dec 2004

Crystal Structure of an Anthrax Toxin -Host Cell Receptor Complex, Oct 2004

A New Groove for the Helix-Turn-Helix Motif: Crystal Structures of the Human DNA Repair Protein AGT Bound to DNA, Sep 2004

Side-on Cu-Nitrosyl Coordination by Nitrite Reductase, Sep 2004

Resurrecting the Dead - Structural Analysis of Hemagglutinin from the 1918 Influenza Pandemic Strain, Aug 2004

Crystal Structures of Anthrax Toxin Lethal Factor Bound to an Optimized Substrate and Candidate Small Molecule Inhibitors, Jun 2004

The Inner Workings of RNA Polymerase: How Genetic Information is Transcribed, Feb 2004

The Crystal Structure of &alpha -Thrombin in Complex with Platelet Glycoprotein (GP) Iba, Jan 2004

Crystal Structures of Mammalian Carboxylesterases and Their Function in Drug and Xenobiotic Metabolism, Aug 2003

Structural Genomics Identify Thymidylate Synthase Complementing Protein as a Novel Antibacterial Drug Target, Jul 2003

Structure of the Specificity Domain of Bacterial RNase P, Apr 2003

Enabling New Science with Advanced Beam Line Control and the Quantum-315 CCD Detector: The Ultra-High Resolution Structure of Nitrogenase MoFe-Protein , Sep 2002

ABC Transporter Architecture and Mechanism, Aug 2002

Towards Understanding Anthrax: Structural Basis of Target Recognition by Anthrax Lethal Factor, Apr 2002

Structure of RNA Polymerase II, Apr 2001