Staff Publications

Highlights:

Web-Ice: integrated data collection and analysis for macromolecular crystallography.

Largest structure (582 KDa a.u.) solved by MAD.

A New X-ray Beamstop with an Integrated Diode Sensor

Faster data-collection strategies for structure determination using anomalous dispersion

An automated system to mount cryo-cooled protein crystals on a synchrotron beamline, using compact sample cassettes and a small-scale robot

Blu-Ice and the Distributed Control System: software for data acquisition and instrument control at macromolecular crystallography beamlines

MAD Phasing of Mb and SP18 with Kr

SSRL is an active member of the Joint Center for Structural Genomics (JCSG) and the Structure Determination Core of JCSG is located at SSRL. For a list of JCSG publications, see http://www.jcsg.org/scripts/prod/publications.cgi

SSRL is also an active member of the Center for High Throughput Structural Biology (CHTSB) concentrating on protein complexes and membrane proteins. The Structure Determination Core resides at the Hauptman-Woodward Medical Research Institute (HWI). For a list of CHTSB publications, see http://www.chtsb.org/Results/Publications/publications.html

Staff Publications

2008

T. I. Doukov, L. C. Blasiak, J. Seravalli, S. W. Ragsdale and C. L. Drennan "Xenon in and at the End of the Tunnel of Bifunctional Carbon Monoxide Dehydrogenase/Acetyl-CoA Synthase." Biochemistry 47, 3474 (2008)

L. J. Byrnes, A. Badarau, S. B. Vakulenko and C. A. Smith "Purification, crystallization and preliminary X-ray analysis of aminoglycoside-2''-phosphotransferase-Ic [APH(2'')-Ic] from Enterococcus gallinarum." Acta Crystallogr. F64, 126 (2008)

A. González, P. Moorhead, S. E. McPhillips, J. Song, K. Sharp, J. R. Taylor, P. D. Adams, N. K. Sauter and S. M. Soltis "Web-Ice: integrated data collection and analysis for macromolecular crystallography." J. Appl. Cryst. 41, 176-184 (2008)

2007

A. A. Hoskins, M. Morar, T. J. Kappock, I. I. Mathews, J. B. Zaugg, T. E. Barder, P.Peng, A. Okamoto, S. E. Ealick and J. Stubbe "N5-CAIR Mutase: Role of a CO2 Binding Site and Substrate Movement in Catalysis." Biochemistry 46, 2842 (2007)

M.L. Paddock, S.E. Wiley, H.L. Axelrod, A. E. Cohen, M. Roy, E. C. Abresch, D. Capraro, A. N. Murphy, R. Nechushtai, J.E. Dixon and P.A. Jennings "MitoNEET is a uniquely folded 2Fe-2S outer mitochondrial membrane protein stabilized by pioglitazone." Proc. Natl. Acad. Sci. USA 104, 14342 (2007)

R. A. Nagatani, A. González, B. K. Shoichet, L. S. Brinen and P. C. Babbitt "Stability for Function Trade-Offs in the Enolase Superfamily 'Catalytic Module'" Biochemistry 46, 6688 (2007)

C. A. Smith, M. Caccamo, K. A. Kantardjieff and S. Vakulenko "The Crystal Structure of GES-1 at Atomic Resolution: Insights into the Evolution of Carbapenamase Activity in the Class A Extended-Spectrum beta-Lactamases" Acta Crystallogr. D63, 982 (2007)

M. Toth, J. Zajicek, C. Kim, J. W. Chow, C. A. Smith, S. Mobashery and S. Vakulenko "Kinetic Mechanism of Enterococcal Aminoglycoside Phosphotransferase 2"-Ib" Biochemistry 46, 5570 (2007)

L. Hannibal, C. A. Smith, D. W. Jacobsen and N. E. Brasch "Nitrosylcob(III)alamin: Synthesis and structural Characterization" Angew. Chemie. 46, 1 (2007)

S. L. Pietranico, L. H. Foley, N. Huby, W. Yun, P. Dunten, J. Vermeulen, P. Wang, K. Toth, G. Ramsey, M-L. Gubler, et al. "C-8 Modifications of 3-alkyl-1,8-dibenzylxanthines as inhibitors of human cytosolic phosphoenolpyruvate carboxykinase" Bioorganic & Medicinal Chemistry Letters. 17, 3835 (2007)

A. González "A comparison of SAD and two-wavelength MAD phasing for radiation-damaged Se-MET crystals" J. Synchrotron Rad. 14, 43 (2007)

T. I. Doukov, H. Hemmi, C. L. Drennan and S. W. Ragsdale, "Structural and Kinetic Evidence for an Extended Hydrogen Bonding Network in Catalysis of Methyl Group Transfer: Role of an Active Site Asparagine Residue in Activation of Methyl Transfer by Methyltransferases", J. Biol. Chem. 282, 6609 (2007)

I. Mathews, M. Soltis, M. Saldajeno, G. Ganshaw, R. Sala, W. Weyler, M. A. Cervin, G. Whited and R. Bott, "Structure of a Novel Enzyme that Catalyzes Acyl Transfer to Alcohols in Aqueous Conditions", Biochemistry 46, 8969 (2007)

J. Song, D. Mathew, S.A. Jacob, L. Corbett, P. Moorhead and S.M. Soltis, "Diffraction-based automated crystal centering" J. Synchrotron Rad. 14, 191 (2007)

2006

M. H. Sazinsky, P. W. Dunten, M. S. McCormick, A. DiDonato and S. J. Lippard "X-ray Structure of a Hydroxylase-Regulatory Protein Complex from a Hydrocarbon-Oxidizing Multicomponent Monooxygenase, Pseudomonas sp. OX1 Phenol Hydroxylase" Biochemistry 45, 15392(2006)

E. Suarez-Moreira, L. Hannibal, C. A. Smith, R. A. Chavez, D. W. Jacobsen and N. E. Brasch, "A simple, convenient method to synthesize cobalamins: Synthesis of homocysteinylcobalamin, N-acetylcysteinylcobalamin, 2-N-acetylamino-2-carbomethoxyethanethiolatocobalamin, sulfitocobalamin and nitrocobalamin", Dalton Trans. 5269 (2006)

T. Deva, E. N. Baker, C. J. Squire and C. A. Smith, "Structure of Escherichia coli UDP-N-acetylmuramoyl:L-alanine ligase (MurC)", Acta Cryst. D62, 1466 (2006)

C. A. Smith, "Structure, function and dynamics in the mur family of bacterial cell wall ligases", J. Mol. Biol. 362 , 640 (2006)

J. Bosch, M. A. Robien, C. Mehlin, E. Boni, A. Riechers, F. S. Buckner, W. C. Van Voorhis, P. J. Myler, E. A. Worthey, G. DeTitta, J. R. Luft, A. Lauricella, S. Gulde, L. A. Anderson, O. Kalyuzhniy, H. M. Neely, J. Ross, T. N. Earnest, M. Soltis, L. Schoenfeld, F. Zucker, E. A. Merritt, E. Fan, C. L. M. J. Verlinde, and W. G. J. Hol "Using Fragment Cocktail Crystallography To Assist Inhibitor Design of Trypanosoma brucei Nucleoside 2-Deoxyribosyltransferase", J. Med. Chem. 49, 5939 (2006)

Y. Tang, H. Y. Lee, Y. Tang, C. -Y. Kim, I. Mathews and C. Khosla "Structural and Functional Studies on SC01815: A β-Ketoacyl-Acyl Carrier Protein Reductase from Streptomyces coelicolor A3(2)", Biochemistry 45, 14085 (2006)

P. G. Young, C. A. Smith, X. Sun, E. N. Baker, and P. Metcalf "Purification, crystallization and preliminary X-ray analysis of Mycobacterium tuberculosis folylpolyglutamate synthase (MtbFPGS)", Acta Cryst. F62, 579 (2006)

C. J. Jackson, P. D. Carr, H. K. Kim, J. W. Liu, P. Herrald, N. Mitic, G. Schenk, C. A. Smith, and D. Ollis "Anomalous scattering analysis of Agrobacterium radiobacter phosphotriesterase: The prominent role of iron in the heterobinuclear active site", Biochem J. 397, 501 (2006)

C. A. Smith, J. A. Cross, and A. L. Bognar, X. Sun "Mutation of Gly51 to serine in the P-loop of Lactobacillus casei folylpolyglutamate synthetase abolishes activity by altering the conformation of two adjacent loops", Acta Cryst. D62, 548 (2006)

M. G. Joyce, C. Levy, K. Gabor, S. M. Pop, B. D. Biehl, T. I. Doukov, J. M. Ryter, H. Mazon, H. Smidt, R. H. van den Heuvel, S. W. Ragsdale, J. van der Oost, and D. Leys "CprK crystal structures reveal mechanism for transcriptional control of halorespiration", J. Biol. Chem. 281, 28318 (2006)

Y. Tang, C. -Y. Kim, I. I. Mathews, D. E. Cane, and C. Khosla, "The 2.7 Å crystal structure of a 194-kDa homodimeric fragment of the 6-deoxyerythronolide B synthase", Proc. Natl. Acad. Sci. USA 103, 11124 (2006)

R. A. Powers, C. L. Rife, A. L. Schilmiller, G. A. Howe, and R. M. Garavito "Structure determination and analysis of acyl-CoA oxidase (ACX1) from tomato", Acta Cryst. D62, 683 (2006)

Z. Zhang, H. van den Bedem, N. K. Sauter, G. Snell, and A. Deacon "Automated diffraction image analysis and spot searching for high-throughput crystal screening", J. Appl. Cryst. 39, 112 (2006)

A. P. Duff, A. E. Cohen, P. J. Ellis, K. Hilmer, D. B. Langley, D. M. Dooley, H. C. Freeman, and J. M. Guss "The 1.23 Å structure of Pichia pastoris lysyl oxidase reveals a lysine-lysine cross-link", Acta Cryst. D62, 1073 (2006)

2005

A. González, A. E. Cohen, T. Eriksson, S. McPhillips, P. Moorhead, J. Narevicius, K. Sharp, C. Smith, J. Song and S. M. Soltis "Facility Updates: Remote Access to the SSRL Macromolecular Crystallography Beamlines", Synchrotron Radiation News, 18, 36 (2005)

A. González, F. von Delft, R. C. Liddington, and C. Bakolitsa, "Two-wavelength MAD Phasing and Radiation Damage: A Case Study", J. Synchrotron Radiat. 12, 285 (2005)

A. E. Cohen, S. E. McPhillips, J. Song, and M. D. Miller "Technical Reports: Automation of High-Throughput Protein Crystal Screening at SSRL", Synchrotron Radiation News, 18 (2), 28 (2005)

L. Shan, I. I. Mathews, and C. Khosla, "Structural and Mechanistic Analysis of Two Prolyl Endopeptidases: Role of Interdomain Dynamics in Catalysis and Specificity", Proc. Natl. Acad. Sci. USA, 109, 3599 (2005)

R. Walanj, P. Young, H. M. Baker, E. N. Baker, P. Metcalf, J. W. Chow, S. Lerner, S. Vakulenko, and C. A. Smith, "Purification, Crystallization and Preliminary X-ray Analysis of Enterococcus faecium Aminoglycoside-2"-Phosphotransferase-Ib [APH(2")-Ib]", Acta Cryst. F61, 410 (2005)

G. L. Card, N. A. Peterson, C. A. Smith, B. Rupp, B. M. Schick, and E. N. Baker "The Crystal Structure of Rv1347c, a Putative Antibiotic Resistance Protein from Mycobacterium tuberculosis, Reveals a GCN5-related Fold and Suggests an Alternative Function in Siderophore Biosynthesis", J. Biol. Chem. 280, 13978 (2005)

E. H. Snell, M. J. van der Woerd, M. D. Miller, and A. M. Deacon. "Finding a cold needle in a warm haystack: infrared imaging applied to locating cryocooled crystals in loops", J. Appl. Cryst. 38, 69 (2005)

E.C. Abresch, H.L. Axelrod, J.T. Beatty, J.A. Johnson, R. Nechustai, and M.L. Paddock "Characterization of a highly purified, fully active, crystallizable RC-LH1-PufX core complex from Rhodobacter sphaeroides", Photosynthesis Research, 86, 61 (2005)

H.L. Axelrod and M.Y. Okamura "The structure and function of the cytochrome c2:reaction center electron transfer complex from Rhodobacter sphaeroides", Photosynthesis Research, 85 101 (2005)

H. van den Bedem, I. Lotan, J.-C. Latombe, and A.M. Deacon "Real-space protein-model completion: an inverse-kinematics approach", Acta Cryst. D61, 2 (2005)

G. L. Card, L. Blasdell, B. P. England, C. Zhang, Y. Suzuki, S. Gillette, D. Fong, P. N. Ibrahim, D. R. Artis, G. Bollag, M. V. Milburn, S. H. Kim, J. Schlessinger, and K. Y. J. Zhang "A family of phosphodiesterase inhibitors discovered by co-crystallography and scaffold-based drug design ", Nat. Biotechnol. 23, 201 (2005)

J. Chappie, J. Canaves, G. Han, C. Rife, Q. Xu, and R. Stevens "The Structure of a Eukaryotic Nicotinic Acid Phosphoribosyltransferase Reveals Structural Heterogeneity among Type II PRTases", Structure, 13, 1385 (2005)

I. Lotan, H. van den Bedem, A.M. Deacon, and J.-C Latombe "Computing Protein Structures from Electron Density Maps: The Missing Loop Problem", In Algorithmic Foundations of Robotics VI, M. Erdmann, M. Overmars, D. Hsu, F. van der Stappen (eds.), Springer Tracts in Advanced Robotics, Vol. 17, Springer-Verlag GmbH, 2005

C. Fabry, M. Rosa-Calatrava, J. Conway, C. Zubieta, S. Cusack, J. Navaza, R. Ruigrok, and G. Schoehn, "A quasi-atomic model of human adenovirus type 5 capsid", EMBO J. 24, 1645 (2005)

J. L. Ferrer, C. Zubieta, R. A. Dixon, and J. P. Noel, "Crystal structures of Alfalfa Caffeoyl Coenzyme A 3-O-methyltransferase", Plant Physiology, 137, 1009 (2006)

C. Zubieta, G. Schoehn, J. Chroboczek, and S. Cusack, "The structure of the human adenovirus 2 penton", Molecular Cell, 17, 121 (2005)

A. Kumar, V. Mandiyan, Y. Suzuki, C. Zhang, J. Rice, J. Tsai, D. R. Artis, P. Ibrahim, and R. Bremer, "Crystal structures of proto-oncogene kinase Pim1: a target of aberrant somatic hypermutations in diffuse large cell lymphoma", J Mol Biol. 348, 183 (2005)

G. Wolf, H. Axelrod, H. van den Bedem, H.-J. Chiu, M. D. Miller, C. L. Rife, Q. Xu and A. M. Deacon "Parallel data processing for high throughput X-ray structure determination", Acta Cryst. A61, C55 (2005)

M. A. Elsliger, A. M. Deacon, A. Godzik, P. Kuhn, S. A. Lesley, R. C. Stevens, K. O. Hodgson, J. Wooley and I. A. Wilson "The Joint Center for Structural Genomics: a multi-tiered approach to structural genomics", Acta Cryst. A61, C257 (2005)

2004

M. D. Miller, L. S. Brinen, A. Cohen, A. M. Deacon, P. Ellis, S. E. McPhillips, T. M. McPhillips, R. P. Phizackerley, S. M. Soltis, H. van den Bedem, G. Wolf, Q. Xu, and Z. Zhang, "Automation of High-Throughput Crystal Screening and Data Collection at SSRL", Proceedings of the International Synchrotron Radiation Instrumentation Conference SRI2003 in San Francisco August 2003, AIP Conference Proceedings, 705, Melville, New York, 1233, (2004)

O. Dgany, A. González, O. Sofer, W. Wang, G. Zolotnitsky, A. Wolf, Y. Shoham, A. Altman, S. G. Wolf, O. Shoseyov, and O. Almog, "The Structural Basis of the Thermostability of SP1, a Novel Plant (Populus tremula) Boiling Stable Protein", J. Biol. Chem. 279, 51516 (2004)

A. P. Duff, D. M. Trambaiolo, A. E. Cohen, P. J. Ellis, G. A. Juda, E. M. Shepard, D. B. Langley, D. M. Dooley, H. C. Freeman, and J. G. Mitchell, "Using Xenon as a Probe for Dioxygen-binding Sites in Copper Amine Oxidases", J. Mol. Biol. 344, 599 (2004)

Q. Xu, H. L. Axelrod, E. C. Abresch, M. L. Paddock, M. Okamura, and G. Feher, "X-ray Structure Determination of Three Mutants of the Bacterial Photosynthetic Reaction Centers from Rb. sphaeroides: Altered Proton Transfer Pathways", Structure 12, 703 (2004)

C. L. Drennan, T. I. Doukov, and S. W. Ragsdale, "The metalloclusters of carbon monoxide dehydrogenase/acetyl-CoA synthase: a story in pictures", J Biol Inorg Chem. 9, 511 (2004)

G. L. Card, B. P. England, Y. Suzuki, D. Fong, B. Powell, B. Lee, C. Luu, M. Tabrizizad, S. Gillette, P. N. Ibrahim, D. R. Artis, G. Bollag, M. V. Milburn, S. H. Kim, J. Schlessinger, and K. Y. J. Zhang "Structural basis for the activity of drugs that inhibit phosphodiesterases", Structure 12, 2233 (2004)

K. Y. J. Zhang, G. L. Card, Y. Suzuki, D. R. Artis, D. Fong, S. Gillette, D. Hsieh, J. Neiman, B. L. West, C. Zhang, M. V. Milburn, S. H. Kim, J. Schlessinger, and G. Bollag, "A Glutamine Switch Mechanism for Nucleotide Selectivity by Phosphodiesterases", Mol. Cell. 15, 279 (2004)

J. E. Ladner, J. F. Parsons, C. L. Rife, G. L. Gilliland, and R. N. Armstrong "Parallel Evolutionary Pathways for Glutathione Transferases: Structure and Mechanism of the Mitochondrial Class Kappa Enzyme rGSTK1-1", Biochemistry, 43, 352 (2004)

S. Pakhomova, C. L. Rife, R. N. Armstrong, and M. E. Newcomer "Crystal Structure of the Fosfomycin Resistance Protein (FosA) from Transposon Tn2921", Protein Science 13, 1260 (2004)

R. E. Rigsby, C. L. Rife, K. L. Fillgrove, M. E. Newcomer, and R. N. Armstrong "Phosphonoformate: A Minimal Transition State Analogue Inhibitor of the Fosfomycin Resistance Protein, FosA", Biochemistry, 43, 13666 (2004)

P. Kota, D. Guo, C. Zubieta, J. Noel, and R. A. Dixon "O-methylation of benzaldehyde derivatives by lignin specific caffeic acid 3-O-methyltransferase", Phytochemistry, 65, 837 (2004)

M. A. Robien, K.T. Nguyen, A. Kumar, I. Hirsh, S. Turley, D. Pei, and W.G.J. Hol, "An improved crystal form of Plasmodium falciparum peptide deformylase", Protein Science, 13, 1155 (2004)

2003

H. Van den Bedem, M. D. Miller, and G. Wolf, "Towards Automated Data Collection at the Stanford Synchrotron Radiation Laboratory", Synchrotron Radiation News, 16, 15 (2003)

A. P. Duff, A. E. Cohen, P. J. Ellis, J. A. Kuchar, D. B. Langley, E. M. Shepard, D. M. Dooley, H. C. Freeman, and J. M. Guss, "The Crystal Structure of Pichia pastoris Lysyl Oxidase", Biochemistry, 42, 15148 (2003)

A. González. "Optimizing data collection for structure determination" Acta Cryst. D59, 1935-1942 (2003)

O. Almog, A. González, D. Klein, H. M. Greenblatt, S. Braun, and G. Shoham. "The 0.93 Å Crystal Structure of Sphericase: A Calcium-loaded Serine Protease from Bacillus sphaericus.",J. Mol. Biol. 332, 1071-1082 (2003)

A. González, S. Benini, and S. Ciurli. "Crystal Structure of Rhodoferax fermentans High Potential Iron-Sulfur Protein Solved by MAD", Acta Cryst. D59, 1582-1588 (2003)

A. Kazantsev, A. A. Krivenko, D. J. Harrington, R. J. Carter, S. R. Holbrook, P. D. Adams, and N. R. Pace, "High-resolution Structure of RNase P Protein from Thermotoga maritima", Proc. Natl. Acad. Sci. USA, 100, 7497 (2003)

I.I. Mathews, A.M. Deacon, J.M. Canaves, D. McMullan, S. A. Lesley, S. Agarwalla, and P. Kuhn, "Functional Analysis of Substrate and Cofactor Complex Structures of a Thymidylate Synthase-Complementing Protein", Structure 11, 677 (2003)

S. Bencharit, C. L. Morton, J. L. Hyatt, P. Kuhn, M. K. Danks, P. M. Potter, and M. R. Redinbo, "Crystal Structure of Human Carboxylesterase 1 Complexed with the Alzheimer's Drug Tacrine: from Binding Promiscuity to Selective Inhibition", Chem. Biol. 10, 341 (2003)

P. J. Ellis, A. E. Cohen, and M. Soltis, "Beamstop with integrated X-ray sensor", J. of Synchrotron Rad. 10, 287 (2003)

A. González, "Faster data-collection strategies for structure determination using anomalous dispersion", Acta. Cryst. D59, 315 (2003)

C. L. Rife, J. F. Parsons, G. Xiao, G. L. Gilliland, and R. N. Armstrong "Conserved Structural Elements in Glutathione Transferase Homologues Encoded in the Genome of Escherichia coli", Proteins: Struct. Func. Gen. 53, 777 (2003)

T. Deva, K.D. Pryor, B. Leiting, E.N. Baker, and C.A. Smith "Purification, crystallization and preliminary X-ray analysis of Escherichia coli UDP-N-acetylmuramoyl-L-alanine ligase (MurC)", Acta. Cryst. D59, 1510 (2003)

E. Liani, L. Rothem, M.A. Bunni, C.A. Smith, G. Jansen, and Y.G. Assaraf "Loss of folylpoly-gamma-glutamate synthetase activity is a dominant mechanism of resistance to polyglutamylation-dependent novel antifolates in multiple human leukemia sublines", Int. J. Cancer, 103, 587 (2003)

D. Nurizzo, S.C. Shewry, M.H. Perlin, S.A. Brown, J.N. Dholakia, R.L. Fuchs, T. Deva, E.N. Baker, and C.A. Smith "The crystal structure of aminoglycoside-3'-phosphotransferase-IIa, an enzyme responsible for antibiotic resistance", J. Mol. Biol. 327, 491 (2003)

C. Zubieta, J. R. Ross, P. Koscheski, Y. Yang, E. Pichersky, and J. P. Noel "Structural basis for substrate recognition in the salicylic acid carboxyl methyltransferase family", Plant Cell, 15, 1704 (2003)

J. P. Noel, R. A. Dixon, E. Pichersky, C. Zubieta, and J. L. Ferrer, "Structural, functional, and evolutionary basis for methylation of plant small molecules", Recent Advances in Phytochemistry, 37, 37 (2003)

J. Moyersoen, J. Choe, A. Kumar, F. G. Voncken, W. G. Hol, and P. A. Michels, "Characterization of Trypanosoma brucei PEX14 and its role in the import of glycosomal matrix proteins", Eur J Biochem. 270, 2059 (2003)

2002

M. D. Miller, A. Cohen, A. Deacon, P. Ellis, P. Kuhn and P. Phizackerley "Automated mounting of cryo-cooled crystals on Stanford synchrotron radiation laboratory beamline 11-1", Acta Cryst. A58, C202 (2002>

A. Deacon, L. Brinen, P. Kuhn, S. McPhillips, T. McPhillips, M. Miller, H. van den Bedem, G. Wolf, J. Zhong and Z. Zhang "A system for the rapid and systematic characterization of protein crystals", Acta Cryst. A58, C299 (2002)

M. Lee, K. Willingham, D. Langley, M. J. Maher, A. E. Cohen, P. J. Ellis, J. A. Kuchar, D. M. Dooley, H. C. Freeman, and J. M. Guss, "Crystallization of Pichia pastoris Lysyl Oxidase", Acta Cryst., D58, 2177 (2002)

L. Huang, L. S. Brinen, and J. A. Ellman, "Crystal Structures of Reversible Ketone-based Inhibitors of the Cysteine Protease Cruzain", Bioorg. Med. Chem. 11, 21 (2003)

Z.-w. Chen, K. Matsushita, T. Yamashita, T.-a. Fujii, H. Toyama, O. Adachi, H. D. Bellamy, and F. S. Mathews, "Structure at 1.9 Å Rsolutton of a Quinohemoprotein Alcohol Dehydrogenase from Pseudomonas putida HK5", Structure, 10, 837 (2002)

A. E. Cohen, P. J. Ellis, M. D. Miller, A. M. Deacon, and R. P. Phizackerley, "An automated system to mount cryo-cooled protein crystals on a synchrotron beamline, using compact samples cassettes and a small-scale robot", J. Appl. Cryst. 35, 720 (2002)

B. Hao, C. Isaza, J. Arndt, M. Soltis, and M. K. Chan, "Structure-based Mechanism of O₂ Sensing and Ligand Discrimination by the FixL Domain of Bradyrhizobium japonicum", Biochemistry, 41, 12952 (2002)

T. M. McPhillips, S. E. McPhillips, H.-J. Chiu, A. E. Cohen, A. M. Deacon, P. J. Ellis, E. Garman, A. González, N. K. Sauter, R. P. Phizackerley, S. M. Soltis, and P. Kuhn, "Blu-Ice and the Distributed Control System: Software for Data Acquisition and Instrument Control at Macromolecular Crystallography Beamlines", J. Synchrotron Rad. 9, 401 (2002)

X. Que, L. S. Brinen, P. Perkins, S. Herdman, K. Hirata, B. E. Torian, H. Rubin, J. H. McKerrow, and S. L. Reed, "Cysteine Proteinases from distinct cellular compartments are recruited to phagocytic vesicles by Entamoeba histolytica", Mol. Biochem. Parisitol. 119, 23 (2002)

P. Kuhn, K. Wilson, M. G. Patch, and R. C. Stevens, "The Genesis of High-throughput Structure-based Drug Discover Using Protein Crystallography", Curr. Opin. Chem. Biol. 6, 704 (2002)

S. A. Lesley, P. Kuhn, A. Godzik, A. M. Deacon, I. I. Mathews, A. Kreusch, G. Spraggon, H. E. Klock, D. McMullan, T. Shin, J. Vincent, A. Robb, L. S. Brinen, M. D. Miller, T. M. McPhillips, M. A. Miller, D. Scheibe, J. M. Canaves, C. Guda, L. Jaroszewski, T. L. Selby, M.-A. Elsliger, J. Wooley, S. S. Taylor, K. O. Hodgson, I. A. Wilson, P. G. Schultz, and R. C. Stevens, "Structural Genomics of the Thermotoga maritima Proteome Implemented in a High-throughput Structure Determination Pipeline", Proc. Natl. Acad. Sci. USA, 99, 11664 (2002)

C. L. Rife, R. E. Pharris, M. E. Newcomer, and R. N. Armstrong "Crystal Structure of a Genomically Encoded Fosfomycin Resistance Protein (FosA) at 1.19 A-Resolution by MAD Phasing of the L-III Edge of Tl+", J. Am. Chem. Soc. 124, 11001 (2002)

S. K. Smoukov, J. Telser, B. A. Bernat, C. L. Rife, R. N. Armstrong, and B. M. Hoffman "EPR Study of Substrate Binding to the Mn(II) Active Site of the Bacterial Antibiotic Resistance Enzyme FosA: A Better Way To Examine Mn(II)", J. Am. Chem. Soc. 124, 2318 (2002)

Y. Sheng, J.A. Cross, Y. Shen, C.A. Smith, and A.L. Bognar "Mutation of an essential glutamate residue in folylpolyglutamate synthetase and activation of the enzyme by pteroate binding", Arch. Biochem. Biophys. 402, 94 (2002)

C.A. Smith, E.N. Baker "Aminoglycoside antibiotic resistance by enzymatic deactivation", Curr. Drug Targets Infect. Dis. 2, 143 (2002)

C. Zubieta, P. Kota, J. L. Ferrer, R. A. Dixon, and J. P. Noel, "Structural basis for the modulation of lignin monomer methylation by caffeic acid/5-hydroxyferulic acid 3/5-O-methyltrasnferase", Plant Cell, 14, 1265 (2002)

D. R. Gang, N. Lavid, C. Zubieta, F. Chen, T. Beuerle, E. Lewinsohn, J. P. Noel, and E. Pichersky, "Characterization of Phenylpropene O-Methyltransferases from Sweet Basil: Facile Change of Substrate Specificity and Convergent Evolution within a Plant O-Methyltrasnferase Family", Plant Cell, 14, 505 (2002)

A. Kumar, K. T. Nguyen, S. Srivathasan, B. Ornstein, S. Turley, I. Hirsh, D. Pei, and W. G. Hol "Crystals of peptide deformylase from Plasmodium falciparum reveal critical characteristics of the active site for drug design", Structure, 10, 357 (2002)

M. C. Merckel, T. Kajander, A. M. Deacon, A. Thompson, J. G. Grossmann, N. Kalkkinen, and A. Goldman, " 3-Carboxy-cis,cis-muconate lactonizing enzyme from Neurospora crassa: MAD phasing with 80 selenomethionines", Acta Cryst., D58, 727 (2002)

2001

U. D. Ramirez, G. Minasov, P. J. Focia, R. M. Stroud, P. Walter, P. Kuhn, and D. M. Freymann, "Structural Basis for Mobility in the 1.1 Å Crystal Structure of the NG Domain of Thermus aquaticus Ffh", J. Mol. Biol. 320, 783 (2002)

C. R. Caffrey, E. Hansell, K.D. Lucas, L. S. Brinen, A.A. Hernandez, J. Cheng, S. L. Gwaltney, W. R. Roush, Y. Stierhof, M. Bogyo, D. Steverding, and J. H. McKerrow, "Active site mapping, biochemical properties and subcellular localization of rhodesain, the major cysteine protease of Trypanosoma brucei rhodesiense", Mol. Biochem. Parisitol. 118: 61 (2001)

W. D. Tolbert , J. L. Ekstrom , I. I. Mathews , J. A. Secrist, P. Kapoor, A. E. Pegg , and S. E. Ealick,"The structural basis for substrate specificity and inhibition of human s-adenosylmethionine decarboxylase", Biochemistry, 40 13124 (2001)

W. D. Tolbert , J. L. Ekstrom , I. I. Mathews , J. A. Secrist, P. Kapoor, A. E. Pegg , and S. E. Ealick, "The structural basis for substrate specificity and inhibition of human S-adenosylmethionine decarboxylase", Biochemistry, 40 9484 (2001)

T. C. Appleby , I. I. Mathews, M. Porcelli, G. Cacciapuoti, and S. E. Ealick, "Three-dimensional Structure of a Hyperthermophilic 5'-Deoxy-5'-methylthioadenosine Phosphorylase from Sulfolobus solfataricus" , J Biol Chem. 276 39232 (2001)

D. H. Peapus, H-J.Chiu, N.Campobasso,J. J. Reddick, T. P. Begley, and S. E. Ealick, "Structural Characterization of the Enzyme-Substrate, Enzyme-Intermediate, and Enzyme-Product Complexes of Thiamin Phosphate Synthase", Biochemistry, 40 10103 (2001)

G. E. O. Borgstahl, A.Vahedi-Faridi, J. Lovelace, H. D.Bellamy, and E. H.Snell, "A test of Macromolecular Crystallization in Microgravity: Large, Well-Ordered Insulin Crystals", Acta Cryst. D57, 1204 (2001)

A. González, G. Larsson, P. Persson, and E. Cedergren-Zeppezauer, "Atomic resolution structure of E. Coli dUTPase determined Ab Initio", Acta Cryst. D57, 767 (2001)

H. J. Chiu , E. Johnson, I. Schröder, and D. C. Rees, "Crystal structure of a novel ferric reductase from the hyperthermophilic archaeon Archaeoglobus fulgidus and it complex with NADP+", Structure, 9, 311 (2001)

P. J. Ellis, T. Conrads, R. Hille, and P. Kuhn, "Crystal structure of the 100 kDa arsenite oxidase from Alcaligenes faecalis in two crystal forms at 1.64 Å and 2.03 Å", Structure, 9, 125 (2001).

A. E. Cohen, P. J. Ellis, N. Kresge, and S. M. Soltis, "MAD phasing with Krypton", Acta Cryst. D57, 233 (2001)

P. S. Sijwali, L. S. Brinen, P. J. Rosenthal, "Systematic optimization of expression and refolding of the Plasmodium falciparum cysteine protease falcipain-2", Protein Expr Purif. 22, 128 (2001)

H. J. Chiu, J. W. Peters, W. N. Lanzilotta, M. J.Ryle , L. C. Seefeldt, J. B. Howard, and D. C. Rees, "MgATP-bound and nucleotide-free structures of a nitrogenase protein complex between the Leu 127 Delta-Fe-protein and the MoFe-protein", Biochemistry, 40, 641 (2001)

C. Caffrey, E. Hansell, K. Lucas, L. S. Brinen, A. Hernandez, J. Cheng, S. Gwaltney, W. Roush, Y. D. Stierhof, M. Bogyo, D. Steverding, and J. McKerrow, "Active Site Mapping, Biochemical Properties and Subcellular Localization of Rhodesain, the Major Cysteine Protease of Trypanosoma Brucei Rhodesiense", Mol. Biochem. Parasitol. 118, 61 (2001)

P. Strop, P. M. Takahara, H. J. Chiu, H. C. Angove, B. K. Burgess, and D. C. Rees, "Crystal structure of the all-ferrous [4Fe-4S](0) form of the nitrogenase iron protein from Azotobacter vinelandii" Biochemistry, 40, 651 (2001)

S. Benedikt, H. J. Chiu, V. Ramakrishnan, J. B. Howard, and D. C. Rees, "Chapter of Nitrogenase", Handbook of Metalloproteins, 1-13 (2001)

M.J. Banfield, M.E. Salvucci, E.N. Baker, and C.A. Smith "The crystal structure of NADP(H)-dependent ketose reductase (sorbitol dehydrogenase) from Besimia argentifolii (silverleaf whitefly) at 2.3 A resolution", J. Mol. Biol. 306, 239 (2001)

X. Sun, J.A. Cross, A.L. Bognar, E.N. Baker, and C.A. Smith "Folate-binding triggers the activation of folylpolyglutamate synthetase", J. Mol. Biol. 310, 1067 (2001)

C. Zubieta, X. . He, R. A. Dixon, and J. P. Noel "Structures of two natural product methyltransferases reveal the basis for substrate specificity in plant O-methyltransferases", Nat. Struct. Biol. 8, 271 (2001)

R. A. Dixon, F. Chen, X. Z. He, J. P. Noel, and C. Zubieta "Properties and metabolic engineering of alfalfa phenylpropanoid pathway O-methyltransferases", Recent Advances in Phytochemistry, 35, 131 (2001)

A. Kumar, C. Roach, I. S. Hirsh, S. Turley, S. deWalque, P. A. M. Michels, and W. G. J. Hol "An Unexpected Extended Conformation for the Third TPR Motif of the Peroxin PEX5 from Trypanosoma brucei", J Mol Biol. 307, 271 (2001)

2000

L. S. Brinen, X. Que, J. H. McKerrow, S. L. Reed, "Homology modeling of Entamoeba histolytica cysteine proteinases reveals the basis for cathepsin L-like structure with cathepsin B-like specificity" Arch. Med. Res. 31, S63 (2000)

L. S. Brinen, E. Hansell, J. Cheng, W. R. Roush, J. H. McKerrow, and R. J. Fletterick, "A target within the target: probing cruzains P1 site to define structural determinants for the Chagas disease protease", Structure, 8, 831 (2000)

N. Campobasso, I. I. Mathews, T. P. Begley, S. E. Ealick, "Crystal structure of 4-methyl-5-beta-hydroxyethylthiazole kinase from Bacillus subtilis at 1.5 Å resolution", Biochemistry, 39, 7868 (2000)

M. A. Schumacher, D. M. Scott, I. I. Mathews, S. E. Ealick, D. S. Roos, B. Ullman, and R. G. Brennan, "Crystal structures of Toxoplasma gondii adenosine kinase reveal a novel catalytic mechanism and prodrug binding", J Mol Biol. 298, 875 (2000)

M. K. Safo, I. Mathews, F. N. Musayev, M. L. di Salvo, D. J. Thiel, D. J. Abraham, and V. Schirch "X-ray structure of Escherichia coli pyridoxine 5'-phosphate oxidase complexed with FMN at 1.8 angstrom resolution", Structure with Folding and Design, 8, 751 (2000)

R. A. Judge, E. H. Snell, L. Crawford, E. L. Forsythe, M. L. Pusey, M. Sporteillo, P .Todd, H. Bellamy, J. Lovelace, J. M. Cossanto, and G .O. Borgstahl, "Investigating the Effect of Impurities on Macromolecule Crystal Growth in Microgravity", Crystal Growth and Design, 1, 151 (2000)

J. H. Thorpe, J. R. Hobbs, A. K. Todd, W. A. Denny, P. Charlton, and C. J. Cardin, "Guanine Specific Binding at a DNA Junction Formed by d[CG(5-BrU)ACG]2 with a Topoisomerase Poison in the Presence of Co2+ Ions", Biochemistry, 39, 15055 (2000)

E. A.Berry, Z. Zhang, H. D. Bellamy, and L. Huang, "Crystallographic Location of two Zn+ Binding Sites in the Avian Cytochrome bc1 Complex", Biochem. Biophys. Acta. Bioenergetics, 1459, 440 (2000)

L. S. Brinen, X. Que, J. H. McKerrow, and S. L. Reed, "Homology modeling of Entamoeba histolytica cysteine proteinases reveals the basis for cathepsin L-like structure with cathepsin B-like specificity", Arch Med Res. 31, S63 (2000)

F. S. Mathews, Z.W.Chen, K. Matsushita, T. Yamashita, H. Toyama, O. Adachi, and H. D. Bellamy, "Structural Studies of a Soluble Monomeric Quinohemoprotein Alcohol Dehydrogenase from Pseudomonas putida HK5 in Biochemistry and Molecular Biology of Vitamin B6 and PQQ-dependent Proteins" Basel, Birkhäuser Verlag, 213-218 (2000)

B. W. Segelke, M. Forstner, M. Knapp, S. Trakhanov, S. Parkin, Y. Newhouse, H. D. Bellamy, K. H. Weisgraber, and B. Rupp, "Conformational Flexibility in the Apolipoprotein E Amino-Terminal Domain Structure Determined from Three New Crystal Forms: Implication for Lipid Binding", Protein Science, 9, 886 (2000)

J. Lovelace, E. H. Snell, M. Pokross, A. S. Arvai, C. Nielsen, N. H. Xuong, H. D. Bellamy, and G. E.O. Borgstahl, "BEAM-ish: a Graphical User Interface for the Physical Characterization of macromolecular Crystals", J. Appl. Cryst., 33, 1187 (2000)

H. D. Bellamy, E. H. Snell, J. Lovelace, M. Pokross, and G. E. O.Borgstahl, "The High Mosaicity Illusion: Revealing the True Physical Characteristics of Macromolecular Crystals", Acta Cryst. D56, 986 (2000)

P. Kuhn, E. Garman, and S. M. Soltis "Limitations in macromolecular crystallography due to radiation damage", Synchrotron Radiat. and Instr. (P. Pianetta, J. Arthur, and S. Brennan, Eds.), 215-218 (2000)

P. J. Ellis, C. K. S. Carlow, D. Ma, and P. Kuhn, "Crystal Structure of the Complex of Brugia malayi Cyclophilin and Cyclosporin A", Biochemistry, 39, 592 (2000)

A. M. Deacon, Y. Ni, W. G. Coleman, and S. E. Ealick, "The crystal structure of ADP-L-glycero-D-mannoheptose 6-epimerase: catalysis with a twist", Structure, 8, 453 (2000)

P. Kuhn, A. M. Deacon, S. Comoso, G. Rajaseger, R. M. Kini, I. Usón, and P. R. Kolatkar, "The atomic resolution structure of bucandin, a novel toxin isolated from the Malayan krait, determined by direct methods" Acta Cryst. D56, 1401 (2000)

S. Benini, A. González, W. R. Rypniewski, K. S. Wilson, J. J. Van Beeumen, and S. Ciurli "Crystal structure of oxidized Bacillus Pasteurii Cytochrome c553 at 0.97 Å resolution. Biochemistry, 39, 13115 (2000)

H. Xu, C. M.Weeks, A. M. Deacon, R. Miller, and H. A. Hauptman, "Ill-conditioned Shake-and-Bake: the trap of the false minimum", Acta Cryst. A56, 112 (2000)

E. Abola, P. Kuhn, T. Earnest, and R. C. Stevens "Automation of x-ray crystallography", Nature Struct. Biol. 7, 973 (2000)

C. L. Kielkopf, S. Ding, P. Kuhn, and D. C. Rees, "Conformational Flexibility of B-DNA at 0.74 Å Resolution: d(CCAGTACTGG)2", J. Mol. Biol., 296, 787 (2000)

P. Luan, A. Heine, K. Zeng, B. Moyer, S. E. Greasely, P. Kuhn, W. E. Balch, and I. A. Wilson, "A New Functional Domain of Guanine Nucleotide Dissociation Inhibitor (a-GDI) Involved in Rab Recycling", Traffic, 1, 270 (2000)

A. P. Yeh, C. Chatelet, S. M. Soltis, P. Kuhn, J. Meyer, and D. C. Rees, "Structure of a Thioredoxin-like [2Fe-2S] Ferredoxin from Aquifex aeolicus", J. Mol. Biol. 300, 587 (2000)

G. L. Card, P. Knowles, H. Laman, N. Jones, and N. Q. McDonald "Crystal Structure of a gamma herpesvirus cyclin-cdk complex", EMBO J. 19, 2877 (2000)

H.M. Baker, C.J. Baker, C.A. Smith, and E.N. Baker "Metal substitution in transferrins: Specific binding of Ce(IV) revealed by the crystal structure of cerium-substituted human lactoferrin", J. Biol. Inorg. Chem. 5, 692 (2000)

R.T. MacGillivray, M.C. Bewley, C.A. Smith, Q.-Y. He, A.B. Mason, R.C. Woodworth, and E.N. Baker "Mutation of the iron ligand His249 to Glu in the N-lobe of human trabsferrin abolishes the dilysine "trigger" but does not significantly affect iron release", Biochemistry, 39, 1211 (2000)

Y. Sheng, X. Sun, Y. Shen, A.L. Bognar, and C.A. Smith "Structural and functional similarities in the ADP-forming amide-bond ligase superfamily: Implications for a substrate-induced conformational change in folylpolyglutamate synthetase", J. Mol. Biol. 302, 427 (2000)

C.A. Smith "Lactoferrin", in Handbook of Metalloproteins. K. Weighardt, R. Huber, T. L. Poulos, A. Messerschmidt. Chichester, John Wiley & Sons, p 812 (2000)

H.S. Toogood, C.A. Smith, R.M. Daniel, and E.N. Baker "Properties of Ak.1 protease, a thermostable subtilisin with a disulphide bond in the substrate-binding cleft", Biochem. J. 350, 321 (2000)

N. Opalka, M. Tihova, C. Brugidou, A. Kumar, R. N. Beachy, C. M. Fauquet, and M. Yeager "Structure of native and expanded sobemoviruses by electron cryo-microscopy and image reconstruction", J Mol Biol. 303, 197 (2000)

1999

J. W. Peters, H. D. Bellamy, "Extension of Fe MAD Phases in the Structure Determination of the Multiple [Fe-S] Cluster Containing Hydrogenase", J. Appl. Cryst. 32, 1180 (1999)

P. A. Williams, N. J. Blackburn, D. Sanders, H. D. Bellamy, E. Stura, J. A. Fee, and D. E. McRee, "The CuA Domain of Thermus thermophilus ba3-type Cytochrome c Oxidase", Nature Struct. Biol. 6, 509 (1999)

I. I. Mathews, T. J. Kappock, J. Stubbe, S. E. Ealick, "Crystal structure of Escherichia coli PurE, an unusual mutase in the purine biosynthetic pathway", Structure Fold Des. 7, 1395 (1999)

C. Munshi, D. J. Thiel, I. I. Mathews, R. Aarhus, T. F. Walseth, H. C. Lee,
"Characterization of the active site of ADP-ribosyl cyclase", J Biol Chem. 274, 30770 (1999)

J. L. Ekstrom, I. I. Mathews, B. A. Stanley, A. E. Pegg, S. E. Ealick, "The crystal structure of human S-adenosylmethionine decarboxylase at 2.25 A resolution reveals a novel fold", Structure Fold Des. 7, 583 (1999)

K. A. Bixby, M. H. Nanao, N. V. Shen, A. Kreusch, H. Bellamy, P. J. Pfaffinger, S. Choe, "Zn2+ -Binding and Molecular Determinants of Tetramerization in Voltage-Gated K+ Channels", Nature Struct. Biol. 6, 38 (1999)

A. González, J.-D. Pédelacq, M. Solà, F. X. Gomis-Rüth, M. Coll, J.-P. Samama and S. Benini. "Two-wavelength MAD phasing: In search of the optimal choice of wavelengths", Acta Cryst. D55, 1449 (1999)

C. J. Cardin, D. J. Cardin, W. Clegg, S. J. Coles, S. P. Constantine, J. R. Rowe (Hobbs), and S. J. Teat, 'The molecular structure and one-pot synthesis of [Li(thf)(3)center dot Sn(SiMe3)(3)]', J. Organomet. Chem. 573, 96 (1999)

H. J. Chiu, J. J. Reddick, T. P.Begley, S. E. Ealick "Crystal structure of thiamin phosphate synthase from Bacillus subtilis at 1.25 Å resolution", Biochemistry, 38, 6460 (1999)

E. Mitchell, P. Kuhn and E. Garman, "Demystifying the Synchrotron Trip: a First Time User's Guide", Structure, 7, 111 (1999)

W. S. Yew, P. R. Kolatkar, P. Kuhn, and H. E. Khoo, "Crystallization and Preliminary Crystallographic Study of Stonustoxin, a Protein Lethal Factor isolated from the Stonefish (Synanceja horrida) Venom", J. Struct. Biol. 128, 216 (1999)

A. M. Deacon and S. E. Ealick, "Selenium-based MAD phasing: setting the sites on larger structures", Structure, 7, R161 (1999)

A. M. Rich, P. J. Ellis, L. Tennant, P. E.Wright, R. S. Armstrong, and P. A. Lay, "Determination of Fe-Ligand Bond Lengths and the Fe-N-O Bond Angles in Soybean Ferrous and Ferric Nitrosylleghemoglobin a Using Multiple-Scattering XAFS Analyses", Biochemistry, 38, 16491 (1999)

M.-C.Cheng, A. M. Rich, R. S .Armstrong, P. J. Ellis, and P. A. Lay, "Determination of Iron-Ligand Bond Lengths in Ferric and Ferrous Horse Heart Cytochrome c Using Multiple-Scattering Analyses of XAFS Data", Inorg. Chem. 38, 5703 (1999)

C. Swanton, G. L. Card, D. Mann, N. McDonald, and N. Jones "Overcoming inhibitions: subversion of CKI function by viral cyclins", TIBS, 24, 116 (1999)

E.N. Baker, C.A. Smith "A retrospective look at an early protein structure refinement: The structure of the cysteine protease actinidin", in Perspectives in Structural Biology. M. Vijayan, N. Yathindra, A. S. Kolaskar. Hyderabad, Universities Press, p 631 (1999)

C.A. Smith, H.S. Toogood, H.M. Baker, R.M. Daniel, and E.N. Baker "Calcium-mediated thermostability in the subtilisin superfamily: The crystal structure of Bacillus Ak.1 protease at 1.8 Å resolution", J. Mol. Biol. 294, 1027 (1999)

G.R. Wolfe, C.A. Smith, D.L. Hendrix, and M.E. Salvucci "Molecular basis of thermoprotection in Bemisia: Structural difference between whitefly ketose reductase and other medium chain dehydrogenases/reductases", Insect Biochem. Mol. Biol. 29, 113 (1999)

A. Kumar, A. Aevarsson, and W. G.J. Hol "Multi-Protein Assemblies with Point Group Symmetry", In Perspectives in Structural Biology, 449-466, Ed. M. Vijayan, N. Yathindra, A. S. Kolaskar, Indian Academy of Sciences and Universities Press (India) Limited.

D. M. Belnap, A. Kumar, J. T. Folk, T. J. Smith, and T. S. Baker "Low-Resolution Density Maps from Atomic Models: How Stepping `Back' Can Be a Step `Forward' ", Journal of Structural Biology, 125, 166 (1999)

L. Ding, Y. Zhang, A. M. Deacon, S. E. Ealick, Y. Ni, P. Sun and W. G. Coleman Jr. " Crystallization and preliminary X-ray diffraction studies of the lipopolysaccharide core biosynthetic enzyme ADP-L-glycero-D- mannoheptose 6-epimerase from Escherichia coli K-12 ", Acta Cryst. D55, 685 (1999)

A. Cassetta, A. M. Deacon, S. E. Ealick, J. R. Helliwell and A. W. Thompson "Development of instrumentation and methods for MAD and structural genomics at the SRS, ESRF, CHESS and Elettra facilities ", J. Synchrotron Rad., 6, 822 (1999)

1998

P. Kuhn, M. Knapp, S. M. Soltis, G. Ganshaw, M. Thoene, and R. Bott, "The 0.78 Å Structure of a Serine Protease, Bacillus lentus Subtilisin", Biochemistry, 37, 13446 (1998)

A. M. Deacon, C. M.Weeks, R. Miller, and S. E. Ealick, "The Shake-and-Bake structure determination of triclinic lysozyme", Proc. Natl. Acad. Sci. USA, 95, 9284 (1998)

M. R. Redinbo, L. Stewart, P. Kuhn, J. J. Champoux, and W.G .J. Hol, "Crystal Structures of Human Topoisomerase I in Covalent and Noncovalent Complexes with DNA", Science, 279,1504 (1998)

I. I. Mathews, M. D. Erion, and S. E. Ealick, "Structure of human adenosine kinase at 1.5 Å resolution", Biochemistry, 37, 15607 (1998)

U. Genick, S. M. Soltis, P. Kuhn, I. L.. Canestrelli, and E. D. Getzoff, "Structure at 0.85 Å Resolution of an Early Protein Photocycle Intermediate", Nature, 392, 206 (1998)

B. E. Bernstein, D. M. Williams, J. C. Bressi, P. Kuhn, M. H. Gelb, G. M. Blackburn, and W. G .J. Hol, "A Bisubstrate Analog Induces Unexpected Conformational Changes in Phosphoglycerate Kinase from Trypanosoma brucel", J. Mol. Biol. 279,1137 (1998)

A. M. Deacon, T. Appleby, D. H. Bilderback, S. E. Ealick, and E. Fontes, D. J. Thiel, "Protein crystallography using a multilayer monochromator", J. Synchrotron Rad. 5, 494 (1998)

A. M. Rich, R. S. Armstrong, P. J. Ellis, H. C. Freeman, and P. A. Lay, "Determination of Iron-Ligand Bond Lengths in Horse Heart Met- and Deoxy-Myoglobin using Multiple-Scattering XAFS" Analyses. Inorg. Chem. 37, 5743 (1998)

A. M. Rich, R. S. Armstrong, P. J. Ellis, and P. A. Lay, "Determination of the Fe-Ligand Bond Lengths and Fe-N-O Bond Angles in Horse Heart Ferric and Ferrous Nitrosylmyoglobin Using Multiple-Scattering XAFS Analyses", J. Am. Chem. Soc. 120, 10827 <1998) (1998)

E. C. Abresch, M. L. Paddock, M. H. B. Stowell, T. M. McPhillips, H. L. Axelrod, S. M. Soltis, D. C. Rees, M. Y. Okamura, and G. Feher, "Identification of Proton Transfer Pathways in the X-ray Crystal Structure of the Bacterial Reaction Center from Rhodobacter sphaeroides", Photosynthesis Research, 55, 119 (1998)

A. F. Arendsen, J. Hadden, G. Card, A. S. McAlpine, S. Bailey, V. Zaitsev, E. H. M. Duke, P. F. Lindley, M. Krockel, A. X. Trautwein, M. C. Feiters, J. M. Charnock, C. D. Garner, S. J. Marritt, A. J. Thomson, I. M. Kooter, M. K. Johnson, W. A. M. van den Berg, W. M. A. M. van Dongen, and W. R. Hagen "The "Prismane" protein resolved: X-ray structure at 1.7 A and multiple spectroscopy of two novel 4Fe clusters", J. Biol. Inorg. Chem. 3, 81 (1998)

R.T. MacGillivray, S.A. Moore, J. Chen, B.F. Anderson, H. Baker, Y. Luo, M. Bewley, C.A. Smith, M.E. Murphy, Y. Wang, A.B. Mason, R.C. Woodworth, G.D. Brayer, and E.N. Baker "Two high-resolution crystal structures of the recombinant N-lobe of human transferrin reveal a structural change implicated in iron release", Biochemistry, 37, 7919 (1998)

X. Sun, A.L. Bognar, E.N. Baker, and C.A. Smith "Structural homologies with ATP- and folate-binding enzymes in the crystal structure of folylpolyglutamate synthetase", Proc. Natl. Acad. Sci. USA, 95, 6647 (1998)

1997

S. M. Soltis, M. H. B. Stowell, M.C. Wiener, G. N. Phillips, and D. C. Rees, "Successful Cryo-Cooling of Xenon Derivatized Myoglobin Crystals", J. Appl. Cryst., 30, 190 (1997)

A. M. Deacon, , T. Gleichmann, A. J. Kalb, H. Price, J. Raftery, G. Bradbrook, J. Yariv, and J. R. Helliwell, "The structure of concanavalin A and its bound solvent determined with small molecule accuracy at 0.94 Å resolution", J. Chem. Soc., Faraday Trans., 93, 4305 (1997)

F. G. Whitby, H. Luecke, P. Kuhn, J. R. Somoza, J. A. Huetze-Perez, J. D. Phillips, C. P. Hill, R. J. Fletterick, and C. C. Wang, "Crystal Structure of Tritrichomonas foetus lnosine-5'-monophosphate Dehydrogenase and the Enzyme Product Complex", Biochemistry, 36,10666 (1997)

M. H. B. Stowell, T. M. McPhillips, D. C. Rees, S. M. Soltis, E. Abresch, and G. Feher, "Light-induced Structural Changes in Photosynthetic Reaction Center: Implications for Mechanism of Electron-Proton Transfer", Science, 276, 812 (1997)

J. W. Peters, M. H. B. Stowell, S. M. Soltis, M. G. Finnegan, M. K. Johnson, and D. C. Rees, "Redox-Dependent Structural Changes in the Nitrogenase P-Cluster", Biochemistry, 36, 1181 (1997)

S. M. Soltis, M. H. B. Stowell, M. C. Wiener, G. N. Phillips, and D. C. Rees, "Successful Flash-Cooling of Xenon Derivatized Myoglobin Crystals", J. Appl. Cryst., 30, 190 (1997)

P. F. Lindley, G. Card, I. Zaitseva, V. Zaitsev, B. Reinhammar, E. Selin-Lindgren, and K. Yoshida "An X-ray structural study of Human Ceruloplasmin in relation to ferroxidase activity", J. Biol. Inorg. Chem. , 2, 454 (1997)

S. Pemberton, P. Lindley, V. Zaitsev, G. Card, E. G. D. Tuddenham, and G. Kemball-Cook, "A molecular model for the triplicated A domains of Human Factor VIII based on the crystal structure of Human Ceruloplasmin", Blood, 89, 2413 (1997)

S. M. Roe, C. Gormal, B. E. Smith, P. Baker, D. Rice, G. Card, and P. Lindley "Crystallisation and preliminary X-ray studies of nitrogenase component 1 ( the MoFe protein) from Klebsiella pneumoniae", Acta Cryst. D53, 227 (1997)

D. Hagrman, C. Zubieta, D. J. Rose, and J. A. Zubieta "Composite solids constructed from one-dimensional coordination polymer matrices and molybdenum oxide subunits: Polyoxomolybdate clusters within [{Cu(4,4'-bpy)}4Mo8O26] and [{Ni(H2O)2(4,4'-bpy)2}2Mo8O26]", Angew. Chem. Int. Ed. Engl. 36, 873 (1997)

1996

M. H. B. Stowell, S. M. Soltis, C. Kisker, J. W. Peters, D. C. Rees, D. Cascio, L. Beamer, P. J. Hart, M. C. Weiner, and F. G. Whitby, "A Simple Device for Studying Macromolecular Crystals Under Moderate Gaseous Pressures (1-100 atm)". J.Appl. Cryst. 29, 608 (1996)

A. Deacon, T. Gleichmann, S. J. Harrop, J. R. Helliwell, A. J. Kalb, and J. Yariv, "Ultra-high resolution protein crystallography: concanavalin A to 0.94 Å and beyond", Rev. Sci. Instrum. 67, 1 (1996)

T. McPhillips, B. Hsu, M. Sherman, M. Mas, and D. C. Rees, "Structure of the R65Q Mutant of Yeast 3-Phosphoglycerate Kinase Complexed with Mg-AMP-PNP and 3-Phospho-D-Glycerate", Biochemistry, 35, 4118 (1996)

J. M. Guss, E. A. Merritt, R. P. Phizackerley and H. C. Freeman, "The Structure of a Phytocyanin, the Basic Blue Protein from Cucumber, Refined at 1.8 Å Resolution", J. Mol. Biol. 262, 686 (1996)

I. I. Mathews, P. A. Vanderhoff-Hanaver, F. J. Castellino, and A. Tulinksy "The Crystal Structures of the Recombinant Kringle 1 Domain of Human Plasminogen in Complexes with the Ligands, E-Amino-caproic Acid and trans-4-Aminomethylhexane-1-Carboxylic Acid", Biochemistry, 35, 2567 (1996)

A. Arendsen, Y. Bulsink, W. Hagen, J. Hadden, G. Card, A. S. McAlpine, S. Bailey, V. Zaitsev, and P. Lindley "Crystallisation and preliminary X-ray crystallographic analysis of the putative [6Fe-6S] prismane protein from Desulfovibrio vulgaris (Hildenborough)", Acta Cryst. D52, 1211 (1996)

I. Zaitseva, V. Zaitsev, G. Card, K. Moshkov, B. Bax, A. Ralph, and P. Lindley "The X-ray structure of Human serum Ceruloplasmin at 3.1 E: Nature of the copper centres", J. Biol. Inorg. Chem. 1, 15 (1996)

H.M. Baker, B.F. Anderson, A.M. Brodie, M.S. Shongwe, C.A. Smith, and E.N. Baker "Anion binding by transferrins: The importance of second-shell effects revealed by the crystal structure of oxalate-substituted diferric lactoferrin", Biochemistry, 35, 9007 (1996)

I. Rayment, C.A. Smith, and R.G. Yount "The active site of myosin", Annu. Rev. Physiol. 58, 671 (1996)

C.A. Smith and I. Rayment "Active Site Comparisons Highlight Structural Similarities between Myosin and other P-Loop Proteins", Biophys. J. 70, 1590 (1996)

C.A. Smith and I. Rayment "Structure of the Vanadate-Trapped ADP Complex of theDictyostelium discoideum Myosin Motor Domain to 1.9-Å Resolution", Biochemistry, 35, 5404 (1996)

C.A. Smith, A.J. Sutherland-Smith, B.K. Keppler, F. Kratz, and E.N. Baker "Binding of Ruthenium(III) Anti-tumor Drugs to Human Lactoferrin Probed by High Resolution X-ray Crystallographic Structure Analysis", J. Biol. Inorg. Chem. 1, 424 (1996)

A. Kumar and M. G. Rossmann "Phase combination", Acta Cryst. , D52, 518 (1996)

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Staff Publications Highlights: Web-Ice: integrated data collection and analysis for macromolecular crystallography. Largest structure (582 KDa a.u.) solved by MAD. A New X-ray Beamstop with an Integrated Diode Sensor Faster data-collection strategies for structure determination using anomalous dispersion An automated system to mount cryo-cooled protein crystals on a synchrotron beamline, using compact sample cassettes and a small-scale robot Blu-Ice and the Distributed Control System: software for data acquisition and instrument control at macromolecular crystallography beamlines MAD Phasing of Mb and SP18 with Kr SSRL is an active member of the Joint Center for Structural Genomics (JCSG) and the Structure Determination Core of JCSG is located at SSRL. For a list of JCSG publications, see http://www.jcsg.org/scripts/prod/publications.cgi SSRL is also an active member of the Center for High Throughput Structural Biology (CHTSB) concentrating on protein complexes and membrane proteins. The Structure Determination Core resides at the Hauptman-Woodward Medical Research Institute (HWI). For a list of CHTSB publications, see http://www.chtsb.org/Results/Publications/publications.html Staff Publications 2008 T. I. Doukov, L. C. Blasiak, J. Seravalli, S. W. Ragsdale and C. L. Drennan "Xenon in and at the End of the Tunnel of Bifunctional Carbon Monoxide Dehydrogenase/Acetyl-CoA Synthase." Biochemistry 47, 3474 (2008) L. J. Byrnes, A. Badarau, S. B. Vakulenko and C. A. Smith "Purification, crystallization and preliminary X-ray analysis of aminoglycoside-2''-phosphotransferase-Ic [APH(2'')-Ic] from Enterococcus gallinarum." Acta Crystallogr. F64, 126 (2008) A. González, P. Moorhead, S. E. McPhillips, J. Song, K. Sharp, J. R. Taylor, P. D. Adams, N. K. Sauter and S. M. Soltis "Web-Ice: integrated data collection and analysis for macromolecular crystallography." J. Appl. Cryst. 41, 176-184 (2008) 2007 A. A. Hoskins, M. Morar, T. J. Kappock, I. I. Mathews, J. B. Zaugg, T. E. Barder, P.Peng, A. Okamoto, S. E. Ealick and J. Stubbe "N5-CAIR Mutase: Role of a CO2 Binding Site and Substrate Movement in Catalysis." Biochemistry 46, 2842 (2007) M.L. Paddock, S.E. Wiley, H.L. Axelrod, A. E. Cohen, M. Roy, E. C. Abresch, D. Capraro, A. N. Murphy, R. Nechushtai, J.E. Dixon and P.A. Jennings "MitoNEET is a uniquely folded 2Fe-2S outer mitochondrial membrane protein stabilized by pioglitazone." Proc. Natl. Acad. Sci. USA 104, 14342 (2007) R. A. Nagatani, A. González, B. K. Shoichet, L. S. Brinen and P. C. Babbitt "Stability for Function Trade-Offs in the Enolase Superfamily 'Catalytic Module'" Biochemistry 46, 6688 (2007) C. A. Smith, M. Caccamo, K. A. Kantardjieff and S. Vakulenko "The Crystal Structure of GES-1 at Atomic Resolution: Insights into the Evolution of Carbapenamase Activity in the Class A Extended-Spectrum beta-Lactamases" Acta Crystallogr. D63, 982 (2007) M. Toth, J. Zajicek, C. Kim, J. W. Chow, C. A. Smith, S. Mobashery and S. Vakulenko "Kinetic Mechanism of Enterococcal Aminoglycoside Phosphotransferase 2"-Ib" Biochemistry 46, 5570 (2007) L. Hannibal, C. A. Smith, D. W. Jacobsen and N. E. Brasch "Nitrosylcob(III)alamin: Synthesis and structural Characterization" Angew. Chemie. 46, 1 (2007) S. L. Pietranico, L. H. Foley, N. Huby, W. Yun, P. Dunten, J. Vermeulen, P. Wang, K. Toth, G. Ramsey, M-L. Gubler, et al. "C-8 Modifications of 3-alkyl-1,8-dibenzylxanthines as inhibitors of human cytosolic phosphoenolpyruvate carboxykinase" Bioorganic & Medicinal Chemistry Letters. 17, 3835 (2007) A. González "A comparison of SAD and two-wavelength MAD phasing for radiation-damaged Se-MET crystals" J. Synchrotron Rad. 14, 43 (2007) T. I. Doukov, H. Hemmi, C. L. Drennan and S. W. Ragsdale, "Structural and Kinetic Evidence for an Extended Hydrogen Bonding Network in Catalysis of Methyl Group Transfer: Role of an Active Site Asparagine Residue in Activation of Methyl Transfer by Methyltransferases", J. Biol. Chem. 282, 6609 (2007) I. Mathews, M. Soltis, M. Saldajeno, G. Ganshaw, R. Sala, W. Weyler, M. A. Cervin, G. Whited and R. Bott, "Structure of a Novel Enzyme that Catalyzes Acyl Transfer to Alcohols in Aqueous Conditions", Biochemistry 46, 8969 (2007) J. Song, D. Mathew, S.A. Jacob, L. Corbett, P. Moorhead and S.M. Soltis, "Diffraction-based automated crystal centering" J. Synchrotron Rad. 14, 191 (2007) 2006 M. H. Sazinsky, P. W. Dunten, M. S. McCormick, A. DiDonato and S. J. Lippard "X-ray Structure of a Hydroxylase-Regulatory Protein Complex from a Hydrocarbon-Oxidizing Multicomponent Monooxygenase, Pseudomonas sp. OX1 Phenol Hydroxylase" Biochemistry 45, 15392(2006) E. Suarez-Moreira, L. Hannibal, C. A. Smith, R. A. Chavez, D. W. Jacobsen and N. E. Brasch, "A simple, convenient method to synthesize cobalamins: Synthesis of homocysteinylcobalamin, N-acetylcysteinylcobalamin, 2-N-acetylamino-2-carbomethoxyethanethiolatocobalamin, sulfitocobalamin and nitrocobalamin", Dalton Trans. 5269 (2006) T. Deva, E. N. Baker, C. J. Squire and C. A. Smith, "Structure of Escherichia coli UDP-N-acetylmuramoyl:L-alanine ligase (MurC)", Acta Cryst. D62, 1466 (2006) C. A. Smith, "Structure, function and dynamics in the mur family of bacterial cell wall ligases", J. Mol. Biol. 362 , 640 (2006) J. Bosch, M. A. Robien, C. Mehlin, E. Boni, A. Riechers, F. S. Buckner, W. C. Van Voorhis, P. J. Myler, E. A. Worthey, G. DeTitta, J. R. Luft, A. Lauricella, S. Gulde, L. A. Anderson, O. Kalyuzhniy, H. M. Neely, J. Ross, T. N. Earnest, M. Soltis, L. Schoenfeld, F. Zucker, E. A. Merritt, E. Fan, C. L. M. J. Verlinde, and W. G. J. Hol "Using Fragment Cocktail Crystallography To Assist Inhibitor Design of Trypanosoma brucei Nucleoside 2-Deoxyribosyltransferase", J. Med. Chem. 49, 5939 (2006) Y. Tang, H. Y. Lee, Y. Tang, C. -Y. Kim, I. Mathews and C. Khosla "Structural and Functional Studies on SC01815: A β-Ketoacyl-Acyl Carrier Protein Reductase from Streptomyces coelicolor A3(2)", Biochemistry 45, 14085 (2006) P. G. Young, C. A. Smith, X. Sun, E. N. Baker, and P. Metcalf "Purification, crystallization and preliminary X-ray analysis of Mycobacterium tuberculosis folylpolyglutamate synthase (MtbFPGS)", Acta Cryst. F62, 579 (2006) C. J. Jackson, P. D. Carr, H. K. Kim, J. W. Liu, P. Herrald, N. Mitic, G. Schenk, C. A. Smith, and D. Ollis "Anomalous scattering analysis of Agrobacterium radiobacter phosphotriesterase: The prominent role of iron in the heterobinuclear active site", Biochem J. 397, 501 (2006) C. A. Smith, J. A. Cross, and A. L. Bognar, X. Sun "Mutation of Gly51 to serine in the P-loop of Lactobacillus casei folylpolyglutamate synthetase abolishes activity by altering the conformation of two adjacent loops", Acta Cryst. D62, 548 (2006) M. G. Joyce, C. Levy, K. Gabor, S. M. Pop, B. D. Biehl, T. I. Doukov, J. M. Ryter, H. Mazon, H. Smidt, R. H. van den Heuvel, S. W. Ragsdale, J. van der Oost, and D. Leys "CprK crystal structures reveal mechanism for transcriptional control of halorespiration", J. Biol. Chem. 281, 28318 (2006) Y. Tang, C. -Y. Kim, I. I. Mathews, D. E. Cane, and C. Khosla, "The 2.7 Å crystal structure of a 194-kDa homodimeric fragment of the 6-deoxyerythronolide B synthase", Proc. Natl. Acad. Sci. USA 103, 11124 (2006) R. A. Powers, C. L. Rife, A. L. Schilmiller, G. A. Howe, and R. M. Garavito "Structure determination and analysis of acyl-CoA oxidase (ACX1) from tomato", Acta Cryst. D62, 683 (2006) Z. Zhang, H. van den Bedem, N. K. Sauter, G. Snell, and A. Deacon "Automated diffraction image analysis and spot searching for high-throughput crystal screening", J. Appl. Cryst. 39, 112 (2006) A. P. Duff, A. E. Cohen, P. J. Ellis, K. Hilmer, D. B. Langley, D. M. Dooley, H. C. Freeman, and J. M. Guss "The 1.23 Å structure of Pichia pastoris lysyl oxidase reveals a lysine-lysine cross-link", Acta Cryst. D62, 1073 (2006) 2005 A. González, A. E. Cohen, T. Eriksson, S. McPhillips, P. Moorhead, J. Narevicius, K. Sharp, C. Smith, J. Song and S. M. Soltis "Facility Updates: Remote Access to the SSRL Macromolecular Crystallography Beamlines", Synchrotron Radiation News, 18, 36 (2005) A. González, F. von Delft, R. C. Liddington, and C. Bakolitsa, "Two-wavelength MAD Phasing and Radiation Damage: A Case Study", J. Synchrotron Radiat. 12, 285 (2005) A. E. Cohen, S. E. McPhillips, J. Song, and M. D. Miller "Technical Reports: Automation of High-Throughput Protein Crystal Screening at SSRL", Synchrotron Radiation News, 18 (2), 28 (2005) L. Shan, I. I. Mathews, and C. Khosla, "Structural and Mechanistic Analysis of Two Prolyl Endopeptidases: Role of Interdomain Dynamics in Catalysis and Specificity", Proc. Natl. Acad. Sci. USA, 109, 3599 (2005) R. Walanj, P. Young, H. M. Baker, E. N. Baker, P. Metcalf, J. W. Chow, S. Lerner, S. Vakulenko, and C. A. Smith, "Purification, Crystallization and Preliminary X-ray Analysis of Enterococcus faecium Aminoglycoside-2"-Phosphotransferase-Ib [APH(2")-Ib]", Acta Cryst. F61, 410 (2005) G. L. Card, N. A. Peterson, C. A. Smith, B. Rupp, B. M. Schick, and E. N. Baker "The Crystal Structure of Rv1347c, a Putative Antibiotic Resistance Protein from Mycobacterium tuberculosis, Reveals a GCN5-related Fold and Suggests an Alternative Function in Siderophore Biosynthesis", J. Biol. Chem. 280, 13978 (2005) E. H. Snell, M. J. van der Woerd, M. D. Miller, and A. M. Deacon. "Finding a cold needle in a warm haystack: infrared imaging applied to locating cryocooled crystals in loops", J. Appl. Cryst. 38, 69 (2005) E.C. Abresch, H.L. Axelrod, J.T. Beatty, J.A. Johnson, R. Nechustai, and M.L. Paddock "Characterization of a highly purified, fully active, crystallizable RC-LH1-PufX core complex from Rhodobacter sphaeroides", Photosynthesis Research, 86, 61 (2005) H.L. Axelrod and M.Y. Okamura "The structure and function of the cytochrome c2:reaction center electron transfer complex from Rhodobacter sphaeroides", Photosynthesis Research, 85 101 (2005) H. van den Bedem, I. Lotan, J.-C. Latombe, and A.M. Deacon "Real-space protein-model completion: an inverse-kinematics approach", Acta Cryst. D61, 2 (2005) G. L. Card, L. Blasdell, B. P. England, C. Zhang, Y. Suzuki, S. Gillette, D. Fong, P. N. Ibrahim, D. R. Artis, G. Bollag, M. V. Milburn, S. H. Kim, J. Schlessinger, and K. Y. J. Zhang "A family of phosphodiesterase inhibitors discovered by co-crystallography and scaffold-based drug design ", Nat. Biotechnol. 23, 201 (2005) J. Chappie, J. Canaves, G. Han, C. Rife, Q. Xu, and R. Stevens "The Structure of a Eukaryotic Nicotinic Acid Phosphoribosyltransferase Reveals Structural Heterogeneity among Type II PRTases", Structure, 13, 1385 (2005) I. Lotan, H. van den Bedem, A.M. Deacon, and J.-C Latombe "Computing Protein Structures from Electron Density Maps: The Missing Loop Problem", In Algorithmic Foundations of Robotics VI, M. Erdmann, M. Overmars, D. Hsu, F. van der Stappen (eds.), Springer Tracts in Advanced Robotics, Vol. 17, Springer-Verlag GmbH, 2005 C. Fabry, M. Rosa-Calatrava, J. Conway, C. Zubieta, S. Cusack, J. Navaza, R. Ruigrok, and G. Schoehn, "A quasi-atomic model of human adenovirus type 5 capsid", EMBO J. 24, 1645 (2005) J. L. Ferrer, C. Zubieta, R. A. Dixon, and J. P. Noel, "Crystal structures of Alfalfa Caffeoyl Coenzyme A 3-O-methyltransferase", Plant Physiology, 137, 1009 (2006) C. Zubieta, G. Schoehn, J. Chroboczek, and S. Cusack, "The structure of the human adenovirus 2 penton", Molecular Cell, 17, 121 (2005) A. Kumar, V. Mandiyan, Y. Suzuki, C. Zhang, J. Rice, J. Tsai, D. R. Artis, P. Ibrahim, and R. Bremer, "Crystal structures of proto-oncogene kinase Pim1: a target of aberrant somatic hypermutations in diffuse large cell lymphoma", J Mol Biol. 348, 183 (2005) G. Wolf, H. Axelrod, H. van den Bedem, H.-J. Chiu, M. D. Miller, C. L. Rife, Q. Xu and A. M. Deacon "Parallel data processing for high throughput X-ray structure determination", Acta Cryst. A61, C55 (2005) M. A. Elsliger, A. M. Deacon, A. Godzik, P. Kuhn, S. A. Lesley, R. C. Stevens, K. O. Hodgson, J. Wooley and I. A. Wilson "The Joint Center for Structural Genomics: a multi-tiered approach to structural genomics", Acta Cryst. A61, C257 (2005) G. Wolf, H. Axelrod, H. van den Bedem, H.-J. Chiu, M. D. Miller, C. L. Rife, Q. Xu and A. M. Deacon "Parallel data processing for high throughput X-ray structure determination", Acta Cryst. A61, C55 (2005) 2004 M. D. Miller, L. S. Brinen, A. Cohen, A. M. Deacon, P. Ellis, S. E. McPhillips, T. M. McPhillips, R. P. Phizackerley, S. M. Soltis, H. van den Bedem, G. Wolf, Q. Xu, and Z. Zhang, "Automation of High-Throughput Crystal Screening and Data Collection at SSRL", Proceedings of the International Synchrotron Radiation Instrumentation Conference SRI2003 in San Francisco August 2003, AIP Conference Proceedings, 705, Melville, New York, 1233, (2004) O. Dgany, A. González, O. Sofer, W. Wang, G. Zolotnitsky, A. Wolf, Y. Shoham, A. Altman, S. G. Wolf, O. Shoseyov, and O. Almog, "The Structural Basis of the Thermostability of SP1, a Novel Plant (Populus tremula) Boiling Stable Protein", J. Biol. Chem. 279, 51516 (2004) A. P. Duff, D. M. Trambaiolo, A. E. Cohen, P. J. Ellis, G. A. Juda, E. M. Shepard, D. B. Langley, D. M. Dooley, H. C. Freeman, and J. G. Mitchell, "Using Xenon as a Probe for Dioxygen-binding Sites in Copper Amine Oxidases", J. Mol. Biol. 344, 599 (2004) Q. Xu, H. L. Axelrod, E. C. Abresch, M. L. Paddock, M. Okamura, and G. Feher, "X-ray Structure Determination of Three Mutants of the Bacterial Photosynthetic Reaction Centers from Rb. sphaeroides: Altered Proton Transfer Pathways", Structure 12, 703 (2004) C. L. Drennan, T. I. Doukov, and S. W. Ragsdale, "The metalloclusters of carbon monoxide dehydrogenase/acetyl-CoA synthase: a story in pictures", J Biol Inorg Chem. 9, 511 (2004) G. L. Card, B. P. England, Y. Suzuki, D. Fong, B. Powell, B. Lee, C. Luu, M. Tabrizizad, S. Gillette, P. N. Ibrahim, D. R. Artis, G. Bollag, M. V. Milburn, S. H. Kim, J. Schlessinger, and K. Y. J. Zhang "Structural basis for the activity of drugs that inhibit phosphodiesterases", Structure 12, 2233 (2004) K. Y. J. Zhang, G. L. Card, Y. Suzuki, D. R. Artis, D. Fong, S. Gillette, D. Hsieh, J. Neiman, B. L. West, C. Zhang, M. V. Milburn, S. H. Kim, J. Schlessinger, and G. Bollag, "A Glutamine Switch Mechanism for Nucleotide Selectivity by Phosphodiesterases", Mol. Cell. 15, 279 (2004) J. E. Ladner, J. F. Parsons, C. L. Rife, G. L. Gilliland, and R. N. Armstrong "Parallel Evolutionary Pathways for Glutathione Transferases: Structure and Mechanism of the Mitochondrial Class Kappa Enzyme rGSTK1-1", Biochemistry, 43, 352 (2004) S. Pakhomova, C. L. Rife, R. N. Armstrong, and M. E. Newcomer "Crystal Structure of the Fosfomycin Resistance Protein (FosA) from Transposon Tn2921", Protein Science 13, 1260 (2004) R. E. Rigsby, C. L. Rife, K. L. Fillgrove, M. E. Newcomer, and R. N. Armstrong "Phosphonoformate: A Minimal Transition State Analogue Inhibitor of the Fosfomycin Resistance Protein, FosA", Biochemistry, 43, 13666 (2004) P. Kota, D. Guo, C. Zubieta, J. Noel, and R. A. Dixon "O-methylation of benzaldehyde derivatives by lignin specific caffeic acid 3-O-methyltransferase", Phytochemistry, 65, 837 (2004) M. A. Robien, K.T. Nguyen, A. Kumar, I. Hirsh, S. Turley, D. Pei, and W.G.J. Hol, "An improved crystal form of Plasmodium falciparum peptide deformylase", Protein Science, 13, 1155 (2004) 2003 H. Van den Bedem, M. D. Miller, and G. Wolf, "Towards Automated Data Collection at the Stanford Synchrotron Radiation Laboratory", Synchrotron Radiation News, 16, 15 (2003) A. P. Duff, A. E. Cohen, P. J. Ellis, J. A. Kuchar, D. B. Langley, E. M. Shepard, D. M. Dooley, H. C. Freeman, and J. M. Guss, "The Crystal Structure of Pichia pastoris Lysyl Oxidase", Biochemistry, 42, 15148 (2003) A. González. "Optimizing data collection for structure determination" Acta Cryst. D59, 1935-1942 (2003) O. Almog, A. González, D. Klein, H. M. Greenblatt, S. Braun, and G. Shoham. "The 0.93 Å Crystal Structure of Sphericase: A Calcium-loaded Serine Protease from Bacillus sphaericus.",J. Mol. Biol. 332, 1071-1082 (2003) A. González, S. Benini, and S. Ciurli. "Crystal Structure of Rhodoferax fermentans High Potential Iron-Sulfur Protein Solved by MAD", Acta Cryst. D59, 1582-1588 (2003) A. Kazantsev, A. A. Krivenko, D. J. Harrington, R. J. Carter, S. R. Holbrook, P. D. Adams, and N. R. Pace, "High-resolution Structure of RNase P Protein from Thermotoga maritima", Proc. Natl. Acad. Sci. USA, 100, 7497 (2003) I.I. Mathews, A.M. Deacon, J.M. Canaves, D. McMullan, S. A. Lesley, S. Agarwalla, and P. Kuhn, "Functional Analysis of Substrate and Cofactor Complex Structures of a Thymidylate Synthase-Complementing Protein", Structure 11, 677 (2003) S. Bencharit, C. L. Morton, J. L. Hyatt, P. Kuhn, M. K. Danks, P. M. Potter, and M. R. Redinbo, "Crystal Structure of Human Carboxylesterase 1 Complexed with the Alzheimer's Drug Tacrine: from Binding Promiscuity to Selective Inhibition", Chem. Biol. 10, 341 (2003) P. J. Ellis, A. E. Cohen, and M. Soltis, "Beamstop with integrated X-ray sensor", J. of Synchrotron Rad. 10, 287 (2003) A. González, "Faster data-collection strategies for structure determination using anomalous dispersion", Acta. Cryst. D59, 315 (2003) C. L. Rife, J. F. Parsons, G. Xiao, G. L. Gilliland, and R. N. Armstrong "Conserved Structural Elements in Glutathione Transferase Homologues Encoded in the Genome of Escherichia coli", Proteins: Struct. Func. Gen. 53, 777 (2003) T. Deva, K.D. Pryor, B. Leiting, E.N. Baker, and C.A. Smith "Purification, crystallization and preliminary X-ray analysis of Escherichia coli UDP-N-acetylmuramoyl-L-alanine ligase (MurC)", Acta. Cryst. D59, 1510 (2003) E. Liani, L. Rothem, M.A. Bunni, C.A. Smith, G. Jansen, and Y.G. Assaraf "Loss of folylpoly-gamma-glutamate synthetase activity is a dominant mechanism of resistance to polyglutamylation-dependent novel antifolates in multiple human leukemia sublines", Int. J. Cancer, 103, 587 (2003) D. Nurizzo, S.C. Shewry, M.H. Perlin, S.A. Brown, J.N. Dholakia, R.L. Fuchs, T. Deva, E.N. Baker, and C.A. Smith "The crystal structure of aminoglycoside-3'-phosphotransferase-IIa, an enzyme responsible for antibiotic resistance", J. Mol. Biol. 327, 491 (2003) C. Zubieta, J. R. Ross, P. Koscheski, Y. Yang, E. Pichersky, and J. P. Noel "Structural basis for substrate recognition in the salicylic acid carboxyl methyltransferase family", Plant Cell, 15, 1704 (2003) J. P. Noel, R. A. Dixon, E. Pichersky, C. Zubieta, and J. L. Ferrer, "Structural, functional, and evolutionary basis for methylation of plant small molecules", Recent Advances in Phytochemistry, 37, 37 (2003) J. Moyersoen, J. Choe, A. Kumar, F. G. Voncken, W. G. Hol, and P. A. Michels, "Characterization of Trypanosoma brucei PEX14 and its role in the import of glycosomal matrix proteins", Eur J Biochem. 270, 2059 (2003) 2002 M. D. Miller, A. Cohen, A. Deacon, P. Ellis, P. Kuhn and P. Phizackerley "Automated mounting of cryo-cooled crystals on Stanford synchrotron radiation laboratory beamline 11-1", Acta Cryst. A58, C202 (2002> A. Deacon, L. Brinen, P. Kuhn, S. McPhillips, T. McPhillips, M. Miller, H. van den Bedem, G. Wolf, J. Zhong and Z. Zhang "A system for the rapid and systematic characterization of protein crystals", Acta Cryst. A58, C299 (2002) M. Lee, K. Willingham, D. Langley, M. J. Maher, A. E. Cohen, P. J. Ellis, J. A. Kuchar, D. M. Dooley, H. C. Freeman, and J. M. Guss, "Crystallization of Pichia pastoris Lysyl Oxidase", Acta Cryst., D58, 2177 (2002) L. Huang, L. S. Brinen, and J. A. Ellman, "Crystal Structures of Reversible Ketone-based Inhibitors of the Cysteine Protease Cruzain", Bioorg. Med. Chem. 11, 21 (2003) Z.-w. Chen, K. Matsushita, T. Yamashita, T.-a. Fujii, H. Toyama, O. Adachi, H. D. Bellamy, and F. S. Mathews, "Structure at 1.9 Å Rsolutton of a Quinohemoprotein Alcohol Dehydrogenase from Pseudomonas putida HK5", Structure, 10, 837 (2002) A. E. Cohen, P. J. Ellis, M. D. Miller, A. M. Deacon, and R. P. Phizackerley, "An automated system to mount cryo-cooled protein crystals on a synchrotron beamline, using compact samples cassettes and a small-scale robot", J. Appl. Cryst. 35, 720 (2002) B. Hao, C. Isaza, J. Arndt, M. Soltis, and M. K. 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