Science Highlights

The science highlights feature high impact research based on data totally or partially collected at the SSRL macromolecular crystallography beamlines. Many of these scientific highlights have been included in reports to funding agencies and have been reported by other media. Users are strongly encouraged to contact SSRL or use the Publication Reporting Form when exciting results are about to be published.

Structure of the TGF-β Receptor Complex Reveals Evolutionary Adaptations that have Led to Diversification of Function within the Superfamily, May 2008

Snapshots of the IL-4 Receptor Ternary Complexes: An Opportunity to Visualize the Basis of Cytokine Receptor Pleiotropy in the Immune System , April 2008

Cooperation of Rab and Arl GTPase Family Members in Localization of the Golgin GCC185 , January 2008

Structures of the GRP94-Nucleotide Complexes Reveal Mechanistic Differences between the Hsp90 Chaperones , January 2008

The Structures of Synaptic Cell Adhesion Proteins Neuroligin-1 in Isolation and in Complex with Neurexin-1&beta Reveal Specific Protein-Protein and Protein-Ca²⁺ Interactions , December 2007

Structure of a Thiol Monolayer-Protected Gold Nanoparticle at 1.1 Å Resolution , December 2007

MitoNEET is a Uniquely Folded Outer Mitochondrial Membrane Protein Stabilized by Diabetes Drugs , October 2007

Structural Insights into the Regulation of the SNARE Assembly by the Cell Polarity Protein Sro7 , July 2007

How a Single T Cell Receptor Recognizes Both Self and Foreign MHC , June 2007

Structure of a Putative Metal-Chelate Type ABC Transporter: An Inward-facing Conformation , May 2007

How Might a Pre-biotic Ribozyme Catalyze RNA Assembly in an RNA world? , April 2007

High Resolution Structure of the Neisseria gonorrhoeae Type IV Pilus: A Membrane-bound Fibrous Assembly. , April 2007

Defining How Botulinum Toxin Binds to the Synaptotagmin Receptor and Creating Improved Therapeutics to Block Toxicity, March 2007

Molecular Interaction between Botulinum Neurotoxin B and Its Protein Receptor Revealed, March 2007

Structure of the MTIP-MyoA Complex, a Key Component of the Malaria Parasite Invasion Motor, January 2007

Structural Studies of the Didomain of a 6-Deoxyerythronolide B Synthase:Largest Structure/Asymmetic Unit Solved by MAD Technique, December 2006

Structural Basis of Transciption: Role of the Trigger Loop in SubstrateSpecificity and Catalysis, December 2006

Structure of GDNF Family Ligand Artemin Complexed with Its GFRα3 Receptor, November 2006

The Elusive Active Fold of a Catalytic RNA: A Crystal Structure of a Full-Length Hammerhead Ribozyme, August 2006

Crystal Structure of Iron-dependent Halogenase, June 2006

Controlling DNA Methylation, June 2006

Crystal Structure Sheds Light on Heriditary Coproporphyria, May 2006

Small-Molecule Inhibition of TNF-alpha, April 2006

High Resolution Snapshots for the Complete Reaction Cycle of a Cocaine Catalytic Antibody, March 2006

Crystal Structure of a Conserved Phosphate Domain of Non-structural Protein-3 (nsp3) from the SARS Coronavirus, March 2006

The Crystal Structure of Human, Nicotine Metabolizing Cytochrome P450 2A6, December 2005

Structure of Human Toll-like Receptor 3 (TLR3) Ligand-Binding Domain, September 2005

Structural Basis for the Promiscuous Biosynthetic Prenylation of Aromatic Natural Products, July 2005

Cytoplasmic Domain Structures of Kir2.1 and Kir3.1 Show Sites for Modulating Gating and Rectification, July 2005

Structure of the ESCRT-II Endosomal Trafficking Complex, Feb 2005

Substrate Recognition Strategy for Botulinum Neurotoxin Serotype A, Dec 2004

Crystal Structure of an Anthrax Toxin -Host Cell Receptor Complex, Oct 2004

A New Groove for the Helix-Turn-Helix Motif: Crystal Structures of the Human DNA Repair Protein AGT Bound to DNA, Sep 2004

Side-on Cu-Nitrosyl Coordination by Nitrite Reductase, Sep 2004

Resurrecting the Dead - Structural Analysis of Hemagglutinin from the 1918 Influenza Pandemic Strain, Aug 2004

Crystal Structures of Anthrax Toxin Lethal Factor Bound to an Optimized Substrate and Candidate Small Molecule Inhibitors, Jun 2004

The Inner Workings of RNA Polymerase: How Genetic Information is Transcribed, Feb 2004

The Crystal Structure of &alpha -Thrombin in Complex with Platelet Glycoprotein (GP) Iba, Jan 2004

Crystal Structures of Mammalian Carboxylesterases and Their Function in Drug and Xenobiotic Metabolism, Aug 2003

Structural Genomics Identify Thymidylate Synthase Complementing Protein as a Novel Antibacterial Drug Target, Jul 2003

Structure of the Specificity Domain of Bacterial RNase P, Apr 2003

Enabling New Science with Advanced Beam Line Control and the Quantum-315 CCD Detector: The Ultra-High Resolution Structure of Nitrogenase MoFe-Protein , Sep 2002

ABC Transporter Architecture and Mechanism, Aug 2002

Towards Understanding Anthrax: Structural Basis of Target Recognition by Anthrax Lethal Factor, Apr 2002

Structure of RNA Polymerase II, Apr 2001